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Title [sv]
Kromatin dynamik i granens gigantiska genom
Title [en]
Chromatin dynamics in the gigantic genome of Norway spruce
Abstract [en]
The genome of Norway spruce is ~150X larger than that of Arabidopsis thaliana and ~40X that of aspen but contains a similar number of genes. There are numerous examples of genomes rendered obese by repetitive DNA element expansions, from axolotl to those of gymnosperms. The underlying reason why these genomes succumbed to runaway repeat expansion remains unresolved. Similarly, it remains unknown whether genomic adaptations have evolved to facilitate the rapid and extensive transcriptome remodulation events that occur during development to counter the mass of non-host DNA.There is currently very little known about how the vast non-coding regions of the Norway spruce genome are organised or the dynamics of chromatin structure in this, or any, gigantic genome.This project will generated Hi-C and ATAC-Seq data to profile chromatin accessibility, interactions and dynamics to test the hypothesis that co-regulated sets of genes involved in large transcriptome remodulation events are arranged into physically proximal clusters that are made accessible for transcription via dynamic chromatin reorganisation. This will provide the first insight into the dynamics and structure of chromatin in one of the numerous gigantic genomes and will identify the functional subset of the genome, which will inform downstream analyses such as genome wide association mapping, functional genomics and regulatory modelling.
Principal InvestigatorStreet, Nathaniel
Coordinating organisation
Umeå University
Funder
Period
2020-01-01 － 2023-12-31
National Category
BotanyBioinformatics and Systems BiologyForest Science
Identifiers
DiVA, id: project:2083Project, id: 2019-05476_VR

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BotanyBioinformatics and Systems BiologyForest Science

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