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Project type/Form of grant
Grant for employment or scholarship
Title [sv]
En molekylär video av ribosombiogenes i Mycobacteria
Title [en]
A molecular movie of ribosome biogenesis in Mycobacteria
Abstract [en]
Declining vaccination coverage, increased migration and emergence of multidrug resistant strains of Mycobacterium tuberculosis, the causative agent of Tuberculosis (TB), cause increased global health risks. With one in four people infected, TB is still a major burden in developing countries. A recent migration wave has led to a rise in active TB cases also in Sweden and novel therapies are needed. The prokaryotic ribosome - the essential machine responsible for all protein synthesis and a major drug target - has been the focus of many biochemical and structural studies unraveling its complex function. Contrarily, its maturation pathway, which requires approximately 50 assembly factors, is poorly understood. Since this pathway is essential and differs significantly between prokaryotes and eukaryotes, it is an attractive target for the development of new antimicrobials.Here we propose to use an innovative combination of in-vivo RNA expression, biochemical analysis and cryo-electron microscopy approaches to determine the assembly process of the mycobacterial ribosome at a molecular level. The analysis will be complemented with targeted chemical library screens to identify novel inhibitors of ribosome assembly factors. The proposed project, scheduled for 4 years, acts at the interface of fundamental and translational research, as it will provide information on an essential pathway in prokaryotes and has the potential to uncover new therapeutic strategies for TB treatment.
Principal InvestigatorBarandun, Jonas
Coordinating organisation
Umeå University
Funder
Period
2020-01-01 － 2023-12-31
National Category
Structural BiologyMicrobiology in the medical area
Identifiers
DiVA, id: project:2105Project, id: 2019-02011_VR

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