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Title [sv]
Exponeringar under fosterstadiet och DNA metylering i navelsträngsblod - tidig prediktion av astma och allergi? - En studie i den prospektiva födelsekohorten NorthPop
Title [en]
The fetal exposome and DNA methylation in cord blood – early prediction of childhood asthma and allergy? – A study in the prospective birth cohort NorthPop
Abstract [en]
An increasing number of children are afflicted by allergies and common signs, such as food sensitivity and eczema, often manifest during the first years of life. The biological mechanisms responsible for allergy development are still unclear but the intrauterine environment is of high importance. One explanation could be that reprogramming of epigenetic marks in fetal DNA (e.g. DNA methylation patterns) increases the risk of asthma and allergy.The overall aim of this study is to build a predictive model for identification of children at high risk of asthma and allergy. Taking advantage of NorthPop – a recently started prospective birth cohort in Northern Sweden - this project will follow 1000 mother-child pairs from pregnancy to 3 years of age. Samples and information from the mothers are collected during pregnancy and cord blood is collected from the newborns. To identify information about the mothers living situation, digital questionnaires are used and environmental pollutants are measured in blood and urine. DNA methylation in cord blood is then connected to lifestyle data. Finally we will use advanced statistical methods to assess if measured differences in DNA methylation can predict allergic risk.This project is uniquely designed to evaluate the impact of the fetal exposome on DNA methylation patterns. The extensive follow up makes it possible to identify mechanisms behind the increase in asthma and allergy and aid in developing predictive strategies for clinical use.
Principal InvestigatorHarlid, Sophia
Coordinating organisation
Umeå University
Funder
Period
2020-01-01 － 2022-12-31
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
DiVA, id: project:2107Project, id: 2019-01187_VR

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