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Project

Project type/Form of grant
Grant for employment or scholarship
Title [sv]
Genreglering och 3D organisation i Glioblastoma: underliggande mekanismer till tumörheterogeneitet och invasivitet
Title [en]
Long-range gene regulation and 3D organization of the Glioblastoma Genome: mechanisms underlying tumor heterogeneity and high invasiveness
Abstract [en]
Glioblastoma (GBM) is the most lethal and aggressive, but also the most common, of all primary brain tumors. Most genetic variants that predispose to cancer are located in non-coding regions enriched in putative enhancers, whose systematic rearrangements have a high impact on gene expression in cancer. Despite the number of susceptibility loci identified in glioblastoma, a functional understanding of how the non-coding regulatory genome contributes to the pathogenesis is missing. Therefore, I aim to study how reprogramming of regulatory regions and topological changes in 3D chromatin organization determine gene dysregulation in glioblastoma, and how this subsequently contributes to malignancy, heterogeneity and invasiveness. To this end, I will bring knowledge from different biological and technical backgrounds into the glioblastoma field, employing next generation sequencing approaches, genome editing and live-cell imaging in both GBM mouse models and human glioma cell lines. The planned research will shed light on how the regulatory and topological architecture of the genome influences malignancy and integrates cues from the neurons in the tumor microenvironment to orchestrate gene expression in glioblastoma. The expected outcome will open up for new therapeutic opportunities in the field of glioblastoma by modulating the regulation of certain genes or the neuron-glioma cell interaction.
Principal InvestigatorRemeseiro, Silvia
Coordinating organisation
Umeå University
Funder
Period
2020-01-01 － 2023-12-31
National Category
Cell and Molecular Biology
Identifiers
DiVA, id: project:2149Project, id: 2019-01960_VR

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