Umeå University's logo

umu.sePublications
EnglishSvenskaNorsk
Change search
ExportLink to record
Permanent link

Direct link
BETA

Project

Project type/Form of grant
Project grant
Title [sv]
Bakteriella fitness mekanismer hos de mångsidiga patogena varianterna av Escherichia coli och den framväxande opportunistiska patogenen Acinetobacter baumannii
Title [en]
Bacterial fitness mechanisms of the versatile pathogenic variants of Escherichia coli and the emerging opportunistic pathogen Acinetobacter baumannii.
Abstract [en]
The purpose is to increase our understanding of the fitness properties and mechanisms by which the very versatile extra-intestinal pathogenic variants of Escherichia coli (ExPEC) and the emerging nosocomial pathogen Acinetobacter baumannii express their virulence-associated properties.Specific aims:To investigate the molecular basis of novel c-di-GMP phosphodiesterases in regulation of ExPEC motility and adhesion.To clarify molecular links between c-di-GMP and filamentation of ExPEC cells.To clarify links between citrate utilization and expression of virulence by ExPECTo investigate if strains with properties of NMEC are represented among isolates from cases of asymptomatic bacteriuria.To perform genomic studies of A. baumannii collections with respect to antibiotic resistance development.To explore a CRISPR-based approach subtyping A. baumannii isolates. To claraify if antibiotic resistance genes are spread via bacterial membrane vesicles.To clarify the role of colony morphotype switching in A. baumannii biofilm formation.To clarify the role of Csu fimbriae in colony morphotype switching and in A. baumannii biofilm formation.To clarify functions of the newly defined C-di-GMP signalling netork in A. baumannii.To elucidate surface properties of A. baumannii that contribute to resistance to desiccation.
Principal InvestigatorUhlin, Bernt Eric
Coordinating organisation
Umeå University
Funder
Period
2020-01-01 － 2022-12-31
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
DiVA, id: project:2153Project, id: 2019-01720_VR
v. 2.46.0
|
WCAG
|
Umeå University Library
|
Register in DiVA
|
Support
|
Search DiVA Portal