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Title [sv]
Obstruktiv Lungsjukdom i Norrbotten - epidemiologiska studier om astma, allergier och KOL sedan 1985
Title [en]
Obstructive Lung Disease in Northern Sweden - epidemiological studies about asthma, allergy and COPD ongoing since 1985.
Abstract [sv]
Asthma and allergic diseases comprise the largest group of diseases among children and up to middle-ages in several countries. The prevalence of asthma in Sweden is 10%. The prevalence of COPD among adults is 10-15%, and 2/100 smokers develop COPD each year. A research program, the Obstructive Lung Disease in Northern Sweden (OLIN) Studies has been developed since 1985 and include descriptive, analytic and interventional epidemiologic research on asthma, allergy, chronic bronchitis, chronic obstructive pulmonary disease (COPD), and obstructive sleep apnea syndrome (OSAS). The over all aims includes identifying risk factors for the diseases and conditions in order to create possibilities for prevention. The studies are multidisciplinary and cover from traditional and molecular epidemiology and clinical research to research about cellular mechanisms, proteomics and genetics. The study samples consist today of ten cohorts of the general population. The aim with the current project is managing and care of large data bases of more than 50,000 subjects in ages 7-89 years. New data are collected continually as most studies are of prospective nature. The ongoing research programs are focused on the natural history of COPD, asthma phenotypes, and trends in prevalence of asthma and sensitisation. Several PhD-thesis are based on the data, and further PhD-students are progressing. The studies include international collaborations. The data bases are an excellent source for future studies.
Publications (2 of 2) Show all publications
Lundquist, A., Lindberg, A., Eriksson Ström, J., Blomberg, A. & Backman, H. (2024). Number of follow-up years needed to identify a rapid decline in FEV1 [Letter to the editor]. American Journal of Respiratory and Critical Care Medicine, 209(1), 119-120
Open this publication in new window or tab >>Number of follow-up years needed to identify a rapid decline in FEV1
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2024 (English)In: American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, E-ISSN 1535-4970, Vol. 209, no 1, p. 119-120Article in journal, Letter (Other academic) Published
Place, publisher, year, edition, pages
American Thoracic Society, 2024
National Category
Respiratory Medicine and Allergy
Research subject
Lung Medicine; Epidemiology
Identifiers
urn:nbn:se:umu:diva-216385 (URN)10.1164/rccm.202309-1664LE (DOI)37879065 (PubMedID)2-s2.0-85181395898 (Scopus ID)
Funder
Swedish Heart Lung FoundationVisare NorrNorrbotten County CouncilUmeå University
Available from: 2023-11-09 Created: 2023-11-09 Last updated: 2024-01-11Bibliographically approved
Backman, H., Blomberg, A., Lundquist, A., Strandkvist, V., Sawalha, S., Nilsson, U., . . . Lindberg, A. (2023). Lung function trajectories and associated mortality among adults with and without airway obstruction. American Journal of Respiratory and Critical Care Medicine, 208(10), 1063-1074
Open this publication in new window or tab >>Lung function trajectories and associated mortality among adults with and without airway obstruction
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2023 (English)In: American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, E-ISSN 1535-4970, Vol. 208, no 10, p. 1063-1074Article in journal (Refereed) Published
Abstract [en]

Rationale: Spirometry is essential for diagnosis and assessment of prognosis in COPD.

Objectives: To identify FEV1 trajectories and their determinants, based on annual spirometry measurements among individuals with and without airway obstruction. Furthermore, to assess mortality in relation to trajectories.

Methods: In 2002-04, individuals with airway obstruction (AO) (FEV1/VC<0.70, n=993) and age- and sex-matched non-obstructive (NO) referents were recruited from population-based cohorts. Annual spirometries until 2014 were utilized in joint-survival Latent Class Mixed Models to identify lung function trajectories. Mortality data were collected during 15 years of follow-up.

Results: Three trajectories were identified among the AO-cases and two among the NO referents. Trajectory membership was driven by baseline FEV1%predicted (%pred) in both groups and additionaly, pack-years in AO and current smoking in NO. Longitudinal FEV1%pred level depended on baseline FEV1%pred, pack-years and obesity. The trajectories were distributed: 79.6% T1AO FEV1-high with normal decline, 12.8% T2AO FEV1-high with rapid decline, and 7.7% T3AO FEV1-low with normal decline (mean 27, 72 and 26 mL/year) among AO-individuals, and 96.7% T1NO FEV1-high with normal decline and 3.3% T2NO FEV1-high with rapid decline (mean 34 and 173 mL/year) among referents. Hazard for death was increased for T2AO (HR1.56) and T3AO (HR3.45) vs. T1AO, and for T2NO (HR2.99) vs. T1NO.

Conclusions: Three different FEV1 trajectories were identified among those with airway obstruction and two among the referents, with different outcomes in terms of FEV1-decline and mortality. The FEV1 trajectories among airway obstructive and the relationship between low FVC and trajectory outcome are of particular clinical interest.

Place, publisher, year, edition, pages
American Thoracic Society, 2023
Keywords
prognosis, chronic obstructive pulmonary disease, FEV1, natural history
National Category
Respiratory Medicine and Allergy
Research subject
Lung Medicine; Epidemiology
Identifiers
urn:nbn:se:umu:diva-212976 (URN)10.1164/rccm.202211-2166oc (DOI)001099650500015 ()37460250 (PubMedID)2-s2.0-85183557430 (Scopus ID)
Funder
Swedish Heart Lung FoundationUmeå UniversityVisare NorrNorrbotten County CouncilSvensk Lungmedicinsk FöreningRegion Västerbotten
Available from: 2023-08-17 Created: 2023-08-17 Last updated: 2024-04-08Bibliographically approved
Principal InvestigatorRönmark, Eva
Coordinating organisation
Umeå University
Funder
Period
2009-01-01 - 2011-12-31
Identifiers
DiVA, id: project:808Project, id: 2008-05867_VR

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