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Title [sv]
Basen för stress och könshormon orsakade mentala symtom och sjukdomar.
Title [en]
Basis for sex and stress hormone induced mood symptoms and diseases
Abstract [sv]
Metabolites of stress and sex hormones (GABA-steroids) agonistically modulate the GABA-A receptor and cause mental symptoms and disorders but the mechanisms are poorly known. Only a few individuals react negatively on GABA-steroids but all individuals have variations in GABA-steroids especially women during the menstrual cycle. The reason for individual responses to GABA-steroids is unknown. Previous research indicates that tolerance development with decreased function in the GABA-A system may be one reason. Another is that GABA-steroids have a biphasic action with low levels provoking symptoms while absence or higher levels give less severe symptoms. Personality factors and chronic stress seem to be of importance. Aims are: In humans investigate if tolerance against GABA-steroids occurs in conditions with increased endogenous or exogenous GABA-steroid exposure by using sensitivity tests of the GABA-A system? With brain imaging studies, in humans, investigate if activity in neural structures responsible for emotions, change in response to stimuli under GABA-steroid influence? In animals studies investigate if psychological trait factors, or chronic social stress, are important for the sensitivity towards GABA-steroids? In HEK-cells, expressing single recombinant human GABA-A receptor, with patch-clamp methods, investigate if 3alpha-hydroxy metabolites of endogenous or therapeutic progestagens, androgens and glucocorticoids are active on the GABA-A receptor?
Principal InvestigatorBäckström, Torbjörn
Coordinating organisation
Umeå University
Funder
Period
2010-01-01 － 2012-12-31
Identifiers
DiVA, id: project:949Project, id: 2009-02637_VR

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