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Title [sv]
Molekylära mekanismer för migration och invasivitet av prostatacancerceller
Title [en]
Molecular mechanisms for migration and invasion of prostate cancer cells
Abstract [sv]
Cancer origins as a result of that epithelial cells undergoes trans-differentiation to a mesenchymal phenotype in a process called EMT, to acquire competence to be able to invade and metastasize. Directed migration of cells is an extremely organized process where the signal from outside of the cell are transmitted via its specific receptors to the inside of the cell, where the responses are further processed via specific adaptor molecules acting as transmitters to assamble specific components of the cytoskeleton, i.e. actin and microtubule with activation of a number of genes, which decide the final outcome of the cellular response. We have identified novel key signaling proteins downstream of the active TGF-b receptors (Smad7, p38 TRAF6, APC, PKCz) which are used to activate stem cell transcription factors in prostate cancer cells. Moreover we have originally found that the TGF-b receptor type I receptor is translocated to the cell nucleus specifically in cancer cells where it probably is directly implicated in gene transcription. We will further explore the biological functions for the proteins described above in oncogenic signals in TGF-b, Wnt and EGF-stimulated prostate cancer cells to understand their roles in migration and invasion. To better understand by which molecular pathways prostate cancer cells is directed to become migratory and invasive will aid for development of novel diagnostic and therapeutic strategies in the future.
Principal InvestigatorLandström, Marene
Coordinating organisation
Umeå University
Funder
Period
2010-01-01 - 2012-12-31
Identifiers
DiVA, id: project:971Project, id: 2009-04405_VR

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