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Project grant
Title [sv]
Mekanismer bakom Epilepsi och Kroniska Smärttillstånd: GABA- och Glycin-Aktiverade Jonkanalers Kontroll av Nervcellers Retbarhet
Title [en]
Mechanisms underlying Epilepsy and Chronic Pain: Control of Neuronal Excitability via GABA- and Glycine-Gated Ion Channels
Abstract [sv]
The project aims at identifying and elucidating the mechanisms that underlie increased neuronal excitability and thereby cause epilepsy and chronic pain. Recent research show that a rise of the intracellular Cl- concentration, which makes the transmitters GABA and glycine excite neurons, may underlie epilepsy as well as chronic pain. The causes of the rise in Cl- concentration are not yet understood. The present project will clarify the mechanisms behind altered Cl- concentration and raised neuronal excitability. We have shown that GABA- and glycine-gated ion channels do not desensitize to the extent previously believed, but may stay open for long durations and affect the Cl- concentration and the cellular excitability. On the basis of these findings, we have formulated, and will test, (i) a hypothesis specifying the conditions for the induction of increased excitability and (ii) a hypothesis that the increased excitability may be reversed to normal by appropriate stimulation! The studies of neuronal excitability are performed by electrophysiological and optical methods with measurements of neuronal impulse activity, ion currents and ion concentrations. The project, with clarifications of cellular mechanisms behind epilepsy and chronic pain, is highly important for the possibilities to prevent such conditions and to treat them effectively.
Principal InvestigatorJohansson, Staffan
Coordinating organisation
Umeå University
Funder
Period
2010-01-01 － 2011-12-31
Identifiers
DiVA, id: project:987Project, id: 2009-03747_VR

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