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Herpesvirus infections, antiviral treatment, and the risk ofdementia: a registry-based cohort study in Sweden
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine. Department of Public Health and Caring Sciences, Geriatric Medicine, Uppsala University, Uppsala, Sweden.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.ORCID iD: 0000-0002-8276-1844
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2021 (English)In: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, E-ISSN 2352-8737, Vol. 7, no 1, article id e12119Article in journal (Refereed) Published
Abstract [en]

Introduction: Herpesviruses, including Herpes simplex virus type 1 (HSV1) and varicella zoster‐virus (VZV), have been implicated in Alzheimer's disease (AD) development. Likewise, antiviral treatment has been suggested to protect against dementia development in herpes‐infected individuals.

Methods: The study enrolled 265,172 subjects aged ≥ 50 years, with diagnoses of VZV or HSV, or prescribed antiviral drugs between 31 December 2005 and 31 December 2017. Controls were matched in a 1:1 ratio by sex and birth year.

Results: Antiviral treatment was associated with decreased risk of dementia (adjusted hazard ratio [HR] 0.89, 95% confidence interval [CI] 0.86 to 0.92), while herpes infection without antiviral drugs increased the risk of dementia (adjusted HR 1.50, 95% CI 1.29 to 1.74).

Discussion: Antiviral treatment was associated with a reduced long‐term risk of dementia among individuals with overt signs of herpes infection. This is consistent with earlier findings indicating that herpesviruses are involved in the pathogenesis of AD.

Place, publisher, year, edition, pages
John Wiley & Sons , 2021. Vol. 7, no 1, article id e12119
Keywords [en]
Alzheimer’s disease, antiviral agents, dementia, herpes simplex, herpes zoster, retrospective cohort study, varicella zoster
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
URN: urn:nbn:se:umu:diva-182629DOI: 10.1002/trc2.12119ISI: 000750546300096Scopus ID: 2-s2.0-85103930201OAI: oai:DiVA.org:umu-182629DiVA, id: diva2:1547684
Available from: 2021-04-27 Created: 2021-04-27 Last updated: 2023-09-05Bibliographically approved

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Lopatko Lindman, KarinHemmingsson, Eva-StinaWeidung, BodilBrännström, JonJosefsson, MariaOlsson, JanElgh, FredrikNordström, PeterLövheim, Hugo

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Lopatko Lindman, KarinHemmingsson, Eva-StinaWeidung, BodilBrännström, JonJosefsson, MariaOlsson, JanElgh, FredrikNordström, PeterLövheim, Hugo
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Geriatric MedicineCentre for Demographic and Ageing Research (CEDAR)StatisticsSection of VirologyWallenberg Centre for Molecular Medicine at Umeå University (WCMM)
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Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Gerontology, specialising in Medical and Health Sciences

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