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Prevalence and correlates of current suicidal ideation in women with premenstrual dysphoric disorder
Department of Women's and Children's Health, Uppsala University Hospital, Uppsala University, Uppsala, Sweden.
Emotion Neuroimaging (EGG) Lab, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynecology.ORCID iD: 0000-0002-4988-1967
Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Department of Gynecology and Reproductive Medicine, Karolinska University Hospital, Stockholm, Sweden.
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2022 (English)In: BMC Women's Health, E-ISSN 1472-6874, Vol. 22, no 1, article id 35Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Although previous studies report an association between Premenstrual Dysphoric Disorder (PMDD) and suicidal ideation, most studies have only established a provisional and retrospective diagnosis of PMDD fundamentally invalidating the diagnosis. Therefore, the aim of this study was to describe the prevalence and to explore correlates of current suicidal ideation in the late luteal phase in women with prospectively assessed and confirmed PMDD.

METHODS: Participants were 110 women who attended the pre-randomization baseline visit of two randomized placebo-controlled clinical trials between January 15, 2017 and October 19, 2019. PMDD was diagnosed prospectively in line with DSM-5 criteria. Current suicidal ideation was measured by the MADRS-S in the late luteal phase. Descriptive statistics were presented and logistic regression analyses were carried out to explore the association between psychosocial and health characteristics and current suicidal ideation, presenting unadjusted odds ratios (OR) and 95% confidence intervals (CI).

RESULTS: Current suicidal ideation was reported by nearly 40% of women with confirmed PMDD (n = 43, 39.1%). Previous psychological treatment for PMDD and higher depressive symptoms in the late luteal phase were positively associated with current suicidal ideation (OR 5.63, 95% CI 1.07-29.49, and OR 1.17, 95% CI 1.10-1.25, respectively), whereas higher ratings of self-rated health were associated with lower odds ratios for current suicidal ideation (OR 0.98, 95% CI 0.96-0.99).

CONCLUSIONS: A substantial proportion of women with confirmed PMDD report current suicidal ideation in the late luteal phase. Results point to a need for better awareness and screening of suicidal ideation in women with PMDD.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2022. Vol. 22, no 1, article id 35
Keywords [en]
MADRS-S, Premenstrual dysphoric disorder (PMDD), Prevalence, Suicidal ideation, Women’s health
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:umu:diva-192641DOI: 10.1186/s12905-022-01612-5ISI: 000754198200007PubMedID: 35148753Scopus ID: 2-s2.0-85124501263OAI: oai:DiVA.org:umu-192641DiVA, id: diva2:1639711
Funder
Swedish Research Council, 2016-01439Swedish Research Council, 2020-01801Swedish Society of Medicine, SLS-573171Swedish Society of Medicine, SLS-597211Swedish Society of Medicine, SLS-789101Swedish Research Council, 2015-00495EU, FP7, Seventh Framework Programme, INCA 600398Available from: 2022-02-22 Created: 2022-02-22 Last updated: 2023-09-05Bibliographically approved

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Bixo, Marie

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