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HSC70 is a novel binding partner involved in the capture of immunoglobulins on B cells in the NOD mouse
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.ORCID iD: 0000-0002-2051-2973
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.ORCID iD: 0000-0002-0273-8485
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.ORCID iD: 0000-0001-5025-6539
2022 (English)In: Autoimmunity, ISSN 0891-6934, E-ISSN 1607-842X, Vol. 55, no 8, p. 520-528Article in journal (Refereed) Published
Abstract [en]

B cells have been shown to be essential for Type 1 diabetes development in the non-obese diabetic mouse, where their contribution as antigen presenting cells has been emphasised. Other important functions for B cells include surface capture of immunoglobulins and transportation of immune complexes, with subsequent endocytosis, antigen processing and antigen presentation. We have previously demonstrated that NOD B cells capture IgM and IgG immune complexes through an unknown surface molecule. In this study, we revealed the presumptive immunoglobulin-binding molecule to be HSC70. Moreover, we detected increased levels of HSC70 on NOD B cells. HSC70 has been shown to play a role in antigen processing and presentation as well as being important in several autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus. Due to its protein stabilising properties, increased HSC70 could contribute to enhanced self-antigen collection and presentation and thereby contribute to the development of Type 1 diabetes.

Place, publisher, year, edition, pages
Taylor & Francis, 2022. Vol. 55, no 8, p. 520-528
Keywords [en]
B lymphocyte, HSC70, immune complex, NOD mouse, Type 1 diabetes
National Category
Immunology in the medical area
Research subject
Immunology
Identifiers
URN: urn:nbn:se:umu:diva-199900DOI: 10.1080/08916934.2022.2117307ISI: 000855330200001PubMedID: 36120986Scopus ID: 2-s2.0-85138421853OAI: oai:DiVA.org:umu-199900DiVA, id: diva2:1700686
Funder
DiabetesfondenSwedish Child Diabetes FoundationAvailable from: 2022-10-03 Created: 2022-10-03 Last updated: 2022-11-29Bibliographically approved

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Renman, EmmaEkici, RifatSundström, MiaLejon, Kristina

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