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Mitochondrial lipids in neurodegeneration
Institute of Molecular Biosciences, University of Graz, Graz, Austria.ORCID iD: 0000-0001-6571-2162
Institute of Molecular Biosciences, University of Graz, Graz, Austria.ORCID iD: 0000-0002-1241-162X
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
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2016 (English)In: Cell and Tissue Research, ISSN 0302-766X, E-ISSN 1432-0878, Vol. 367, no 1, p. 125-140Article in journal (Other academic) Published
Abstract [en]

Mitochondrial dysfunction is a common feature of many neurodegenerative diseases, including proteinopathies such as Alzheimer’s or Parkinson’s disease, which are characterized by the deposition of aggregated proteins in the form of insoluble fibrils or plaques. The distinct molecular processes that eventually result in mitochondrial dysfunction during neurodegeneration are well studied but still not fully understood. However, defects in mitochondrial fission and fusion, mitophagy, oxidative phosphorylation and mitochondrial bioenergetics have been linked to cellular demise. These processes are influenced by the lipid environment within mitochondrial membranes as, besides membrane structure and curvature, recruitment and activity of different proteins also largely depend on the respective lipid composition. Hence, the interaction of neurotoxic proteins with certain lipids and the modification of lipid composition in different cell compartments, in particular mitochondria, decisively impact cell death associated with neurodegeneration. Here, we discuss the relevance of mitochondrial lipids in the pathological alterations that result in neuronal demise, focussing on proteinopathies.

Place, publisher, year, edition, pages
Springer, 2016. Vol. 367, no 1, p. 125-140
Keywords [en]
Mitochondria, Lipids, Neurodegeneration, Mitochondrial dynamics, Mitochondria-associated membranes
National Category
Cell Biology Biochemistry and Molecular Biology Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-215040DOI: 10.1007/s00441-016-2463-1ISI: 000391387300011PubMedID: 27449929Scopus ID: 2-s2.0-84979503766OAI: oai:DiVA.org:umu-215040DiVA, id: diva2:1802943
Funder
Swedish Research Council, 2015-05468Available from: 2023-10-06 Created: 2023-10-06 Last updated: 2023-10-16Bibliographically approved

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Kohler, AndreasKohler, Verena

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