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Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Farmakologi.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Farmakologi.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Farmakologi.
2016 (engelsk)Inngår i: British Journal of Clinical Pharmacology, ISSN 0306-5251, E-ISSN 1365-2125, Vol. 82, nr 4, s. 932-942Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Palmitoylethanolamide (PEA) has been suggested to have useful analgesic properties and to be devoid of unwanted effects. Here, we have examined critically this contention, and discussed available data concerning the pharmacokinetics of PEA and its formulation. Sixteen clinical trials, six case reports/pilot studies and a meta-analysis of PEA as an analgesic have been published in the literature. For treatment times up to 49days, the current clinical data argue against serious adverse drug reactions (ADRs) at an incidence of 1/200 or greater. For treatment lasting more than 60days, the number of patients is insufficient to rule out a frequency of ADRs of less than 1/100. The six published randomized clinical trials are of variable quality. Presentation of data without information on data spread and nonreporting of data at times other than the final measurement were among issues that were identified. Further, there are no head-to-head clinical comparisons of unmicronized vs. micronized formulations of PEA, and so evidence for superiority of one formulation over the other is currently lacking. Nevertheless, the available clinical data support the contention that PEA has analgesic actions and motivate further study of this compound, particularly with respect to head-to-head comparisons of unmicronized vs. micronized formulations of PEA and comparisons with currently recommended treatments.

sted, utgiver, år, opplag, sider
2016. Vol. 82, nr 4, s. 932-942
Emneord [en]
adverse drug reactions, clinical trials, inflammation, pain, pharmacokinetics, Palmitoylethanolamide
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-130060DOI: 10.1111/bcp.13020ISI: 000383685700004PubMedID: 27220803Scopus ID: 2-s2.0-84986296799OAI: oai:DiVA.org:umu-130060DiVA, id: diva2:1064806
Tilgjengelig fra: 2017-01-13 Laget: 2017-01-11 Sist oppdatert: 2023-03-24bibliografisk kontrollert

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Gabrielsson, LindaMattsson, SofiaFowler, Christopher J.

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