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Synthesis of Various N-Substituted 4-Aryloxy/Thiophenoxy/Thioisopropyloxy-Phthalimides
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. Guru Nanak Dev Univ, Punjab, India.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
2017 (engelsk)Inngår i: ChemistrySelect, ISSN 2365-6549, Vol. 2, nr 11, s. 3293-3296Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

N-substituted phthalimides have been used to target many biological systems with examples that are clinically used as drugs. Furthermore, N-substituted phthalimides can also be used in other settings such as in the preparation of polymers, as catalysts, and as protective groups. Because of all these important fields of application, the synthesis of phthalimides is well reported. However, synthetic methods to phthalimides with different heteroatom substituents in position 4 are lacking. The present work describes the development of robust synthetic methods to N-substituted 4-aryloxy/thiophenoxy/thioisopropyloxy-phthalimides. The developed methods allow for the introduction of these substituents through an atom efficient one-step synthesis, which gives good to excellent yields and tolerate a wide range of substituents.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2017. Vol. 2, nr 11, s. 3293-3296
Emneord [en]
Green synthesis, Methodology and Reactions, Microwave synthesis, Nucleophilic substitution, Phthalimide
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Identifikatorer
URN: urn:nbn:se:umu:diva-134548DOI: 10.1002/slct.201700721ISI: 000399332800013Scopus ID: 2-s2.0-85041718373OAI: oai:DiVA.org:umu-134548DiVA, id: diva2:1093923
Tilgjengelig fra: 2017-05-08 Laget: 2017-05-08 Sist oppdatert: 2023-03-24bibliografisk kontrollert

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