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Quantitative Comparison Of Vesicular Glutamate Transporters in rat Deep Cerebellar Nuclei
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB). Department of Cognitive Neurology, HIH for Clinical Brain Research, Tübingen, Germany.ORCID-id: 0000-0001-9194-9905
2018 (engelsk)Inngår i: Neuroscience, ISSN 0306-4522, E-ISSN 1873-7544, Vol. 376, s. 152-161Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The excitatory synapses of the rat deep cerebellar nuclei (DCN) were quantitatively analyzed by vesicular glutamate transporter 1 and 2 (vGluT1 and vGluT2) immunolabeling. We calculated the number and sizes of the labeled boutons and compared them between lateral/dentate nucleus (LN/DN), posterior interposed nucleus (PIN), anterior interposed nucleus (AIN), and medial nucleus (MN). The density of vGluT1+ boutons differs significantly within these nuclei. In contrast, the vGluT2+ bouton density is more similar between different nuclei. The phylogenetically newer DCN (LN/DN and PIN) have a 39% higher density of vGluT1+ boutons than the phylogenetically older DCN (AIN and MN). The volume of vGluT1+ boutons does not differ between the DCN, however the average volume of vGluT2+ boutons is larger in MN. In summary, our current results confirm and extend our previous findings showing that the increase in dendritic and axonal wiring in phylogenetically newer DCN is associated with an increase in vGluT1+ bouton density.

sted, utgiver, år, opplag, sider
2018. Vol. 376, s. 152-161
Emneord [en]
vesicular glutamate transporter, quantitative analysis, bouton density, bouton size, deep cerebellar nuclei
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-146035DOI: 10.1016/j.neuroscience.2018.02.020ISI: 000427828400013PubMedID: 29462701Scopus ID: 2-s2.0-85042858919OAI: oai:DiVA.org:umu-146035DiVA, id: diva2:1193438
Tilgjengelig fra: 2018-03-27 Laget: 2018-03-27 Sist oppdatert: 2023-03-24bibliografisk kontrollert

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