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The impact of the Lewis number, Le, on the dynamics and morphology of a premixed flame front, spreading through a toothbrush-like array of obstacles in a semi-open channel, is studied by means of the computational simulations of the reacting flow equations with fully-compressible hydrodynamics and Arrhenius chemical kinetics. The computational approach employs a cell-centered, finite-volume numerical scheme, which is of the 2nd-order accuracy in time, 4th-order in space for the convective terms, and of the 2nd-order in space for the diffusive terms. The channels of blockage ratios 0.33∼0.67 are considered, with the Lewis numbers in the range 0.2≤Le≤2.0 employed. It is shown that the Lewis number influences the flame evolution substantially. Specifically, flame acceleration weakens for Le>1 (inherent to fuel-lean hydrogen or fuel-rich hydrocarbon burning), presumably, due to a thickening of the flame front. In contrast, Le<1 flames (such as that of rich hydrogen or lean hydrocarbon) acquire an extra strong folding of the front and thereby accelerate even much faster. The later effect can be devoted to the onset of the diffusional-Thermal combustion instability. © 2018 Eastern States Section of the Combustion Institute. All rights reserved.