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Herpesvirus infections, antiviral treatment, and the risk ofdementia: a registry-based cohort study in Sweden
Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Geriatrik.
Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Geriatrik.
Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Geriatrik. Department of Public Health and Caring Sciences, Geriatric Medicine, Uppsala University, Uppsala, Sweden.
Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Geriatrik.ORCID-id: 0000-0002-8276-1844
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2021 (engelsk)Inngår i: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, E-ISSN 2352-8737, Vol. 7, nr 1, artikkel-id e12119Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Introduction: Herpesviruses, including Herpes simplex virus type 1 (HSV1) and varicella zoster‐virus (VZV), have been implicated in Alzheimer's disease (AD) development. Likewise, antiviral treatment has been suggested to protect against dementia development in herpes‐infected individuals.

Methods: The study enrolled 265,172 subjects aged ≥ 50 years, with diagnoses of VZV or HSV, or prescribed antiviral drugs between 31 December 2005 and 31 December 2017. Controls were matched in a 1:1 ratio by sex and birth year.

Results: Antiviral treatment was associated with decreased risk of dementia (adjusted hazard ratio [HR] 0.89, 95% confidence interval [CI] 0.86 to 0.92), while herpes infection without antiviral drugs increased the risk of dementia (adjusted HR 1.50, 95% CI 1.29 to 1.74).

Discussion: Antiviral treatment was associated with a reduced long‐term risk of dementia among individuals with overt signs of herpes infection. This is consistent with earlier findings indicating that herpesviruses are involved in the pathogenesis of AD.

sted, utgiver, år, opplag, sider
John Wiley & Sons , 2021. Vol. 7, nr 1, artikkel-id e12119
Emneord [en]
Alzheimer’s disease, antiviral agents, dementia, herpes simplex, herpes zoster, retrospective cohort study, varicella zoster
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-182629DOI: 10.1002/trc2.12119ISI: 000750546300096Scopus ID: 2-s2.0-85103930201OAI: oai:DiVA.org:umu-182629DiVA, id: diva2:1547684
Tilgjengelig fra: 2021-04-27 Laget: 2021-04-27 Sist oppdatert: 2023-09-05bibliografisk kontrollert

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Lopatko Lindman, KarinHemmingsson, Eva-StinaWeidung, BodilBrännström, JonJosefsson, MariaOlsson, JanElgh, FredrikNordström, PeterLövheim, Hugo

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