Umeå University's logo

umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Site-selected thionated benzothioxanthene chromophores as heavy-atom-free small-molecule photosensitizers for photodynamic therapy
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk kemi och biofysik.ORCID-id: 0000-0002-7815-4494
Univ Angers, CNRS, MOLTECH-ANJOU, SFR MATRIX, Angers, France.
Univ Angers, CNRS, MOLTECH-ANJOU, SFR MATRIX, Angers, France.
Univ Angers, CNRS, MOLTECH-ANJOU, SFR MATRIX, Angers, France.
Vise andre og tillknytning
2022 (engelsk)Inngår i: Communications Chemistry, E-ISSN 2399-3669, Vol. 5, artikkel-id 142Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Photodynamic therapy is a clinically approved anticancer modality that employs a light-activated agent (photosensitizer) to generate cytotoxic reactive oxygen species (ROS). There is therefore a growing interest for developing innovative photosensitizing agents with enhanced phototherapeutic performances. Herein, we report on a rational design synthetic procedure that converts the ultrabright benzothioxanthene imide (BTI) dye into three heavy-atom-free thionated compounds featuring close-to-unit singlet oxygen quantum yields. In contrast to the BTI, these thionated analogs display an almost fully quenched fluorescence emission, in agreement with the formation of highly populated triplet states. Indeed, the sequential thionation on the BTI scaffold induces torsion of its skeleton reducing the singlet-triplet energy gaps and enhancing the spin-orbit coupling. These potential PSs show potent cancer-cell ablation under light irradiation while remaining non-toxic under dark condition owing to a photo-cytotoxic mechanism that we believe simultaneously involves singlet oxygen and superoxide species, which could be both characterized in vitro. Our study demonstrates that this simple site-selected thionated platform is an effective strategy to convert conventional carbonyl-containing fluorophores into phototherapeutic agents for anticancer PDT.

sted, utgiver, år, opplag, sider
Springer Nature, 2022. Vol. 5, artikkel-id 142
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-200995DOI: 10.1038/s42004-022-00752-xISI: 000876981400002Scopus ID: 2-s2.0-85140992916OAI: oai:DiVA.org:umu-200995DiVA, id: diva2:1711476
Forskningsfinansiär
Swedish Cancer Society, 21 0302 PT 01 HSwedish Cancer Society, 2019/126Swedish Research Council, 2021-02468EU, Horizon 2020, 722651
Merknad

We acknowledge the Biochemical Imaging Center at Umeå University and the National Microscopy Infrastructure, NMI (VR-RFI 2019-00217) for providing assistance in microscopy.

Tilgjengelig fra: 2022-11-17 Laget: 2022-11-17 Sist oppdatert: 2022-11-17bibliografisk kontrollert

Open Access i DiVA

fulltext(3097 kB)92 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 3097 kBChecksum SHA-512
6be87c5ecfc281f85ca414a0ed6538c682fdff4d1126368b56b1f9b0645eb042b972b212539b8b794cfd88821d12afdcc4256988ce20d169b3a8631a1c176a24
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstScopus

Person

Deiana, MarcoSabouri, Nasim

Søk i DiVA

Av forfatter/redaktør
Deiana, MarcoSabouri, Nasim
Av organisasjonen
I samme tidsskrift
Communications Chemistry

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 92 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 254 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf