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Regulatory roles of RNA modifications in breast cancer
Umeå universitet, Medicinska fakulteten, Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM). Umeå universitet, Medicinska fakulteten, Institutionen för molekylärbiologi (Medicinska fakulteten).
Umeå universitet, Medicinska fakulteten, Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM). Umeå universitet, Medicinska fakulteten, Institutionen för molekylärbiologi (Medicinska fakulteten).ORCID-id: 0000-0002-5389-244x
Umeå universitet, Medicinska fakulteten, Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM). Umeå universitet, Medicinska fakulteten, Institutionen för molekylärbiologi (Medicinska fakulteten).ORCID-id: 0000-0002-2374-2045
2021 (engelsk)Inngår i: NAR Cancer, E-ISSN 2632-8674, Vol. 3, nr 3, artikkel-id zcab036Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Collectively referred to as the epitranscriptome, RNA modifications play important roles in gene expression control regulating relevant cellular processes. In the last few decades, growing numbers of RNA modifications have been identified not only in abundant ribosomal (rRNA) and transfer RNA (tRNA) but also in messenger RNA (mRNA). In addition, many writers, erasers and readers that dynamically regulate the chemical marks have also been characterized. Correct deposition of RNA modifications is prerequisite for cellular homeostasis, and its alteration results in aberrant transcriptional programs that dictate human disease, including breast cancer, the most frequent female malignancy, and the leading cause of cancer-related death in women. In this review, we emphasize the major RNA modifications that are present in tRNA, rRNA and mRNA. We have categorized breast cancer-associated chemical marks and summarize their contribution to breast tumorigenesis. In addition, we describe less abundant tRNA modifications with related pathways implicated in breast cancer. Finally, we discuss current limitations and perspectives on epitranscriptomics for use in therapeutic strategies against breast and other cancers.

sted, utgiver, år, opplag, sider
Oxford University Press, 2021. Vol. 3, nr 3, artikkel-id zcab036
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URN: urn:nbn:se:umu:diva-202959DOI: 10.1093/narcan/zcab036ISI: 000925411800012PubMedID: 34541538Scopus ID: 2-s2.0-85126281516OAI: oai:DiVA.org:umu-202959DiVA, id: diva2:1727021
Tilgjengelig fra: 2023-01-14 Laget: 2023-01-14 Sist oppdatert: 2023-09-05bibliografisk kontrollert

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Kumari, KanchanGroza, PaulaAguilo, Francesca

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