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Serological Evidence of Exposure to Onyong-Nyong and Chikungunya Viruses in Febrile Patients of Rural Taita-Taveta County and Urban Kibera Informal Settlement in Nairobi, Kenya
KAVI Institute of Clinical Research, University of Nairobi, POB 19676, Nairobi, Kenya; Department of Medical Microbiology, University of Nairobi, POB 19676, Nairobi, Kenya.
Department of Virology, University of Helsinki, Helsinki, Finland; Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
Department of Virology, University of Helsinki, Helsinki, Finland; HUS Diagnostic Center, HUSLAB, Virology and Immunology, Helsinki University Hospital, Helsinki, Finland.
Department of Virology, University of Helsinki, Helsinki, Finland; Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland; Department of Geosciences and Geography, University of Helsinki, Helsinki, Finland.
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2022 (engelsk)Inngår i: Viruses, E-ISSN 1999-4915, Vol. 14, nr 6, artikkel-id 1286Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Several alphaviruses, such as chikungunya (CHIKV) and Onyong-nyong (ONNV), are endemic in Kenya and often cause outbreaks in different parts of the country. We assessed the seroprevalence of alphaviruses in patients with acute febrile illness in two geographically distant areas in Kenya with no previous record of alphavirus outbreaks. Blood samples were collected from febrile patients in health facilities located in the rural Taita-Taveta County in 2016 and urban Kibera informal settlement in Nairobi in 2017 and tested for CHIKV IgG and IgM antibodies using an in-house immunofluorescence assay (IFA) and a commercial ELISA test, respectively. A subset of CHIKV IgG or IgM antibody-positive samples were further analyzed using plaque reduction neutralization tests (PRNT) for CHIKV, ONNV, and Sindbis virus. Out of 537 patients, 4 (0.7%) and 28 (5.2%) had alphavirus IgM and IgG antibodies, respectively, confirmed on PRNT. We show evidence of previous and current exposure to alphaviruses based on serological testing in areas with no recorded history of outbreaks.

sted, utgiver, år, opplag, sider
MDPI, 2022. Vol. 14, nr 6, artikkel-id 1286
Emneord [en]
alphavirus, arbovirus, chikungunya, ELISA, febrile illness, immunofluorescence, neutralization, Onyong-nyong, seroprevalence
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-203180DOI: 10.3390/v14061286ISI: 000818334100001PubMedID: 35746757Scopus ID: 2-s2.0-85132365824OAI: oai:DiVA.org:umu-203180DiVA, id: diva2:1727454
Forskningsfinansiär
Academy of FinlandTilgjengelig fra: 2023-01-16 Laget: 2023-01-16 Sist oppdatert: 2024-01-17bibliografisk kontrollert

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