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Erythrocytosis, thrombocytosis, and rate of recurrent thromboembolic event: a population based cohort study
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.ORCID-id: 0000-0002-9984-3520
NU Hospital Group, Uddevalla, Sweden.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.ORCID-id: 0000-0001-6206-3099
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper.
Vise andre og tillknytning
2023 (engelsk)Inngår i: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 110, nr 6, s. 608-617Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Introduction: The management to reduce risk of thromboembolic complications in polycythemia vera and essential thrombocythemia are well established, but for other conditions with elevated hemoglobin, hematocrit, or platelets there are no consensus regarding treatment and follow up.

Aims: To assess frequency of elevated blood values in patients with thromboembolic event, how many of these should be investigated further regarding myeloproliferative neoplasm and if the risk of recurrent event is depending on underlying condition.

Methods: Retrospective cohort study of 3931 adult patients in the county of Norrbotten, Sweden, with thromboembolism during 2017 and 2018.

Results: Of the 3931 patients, 1195 had either elevated Hb, HCT, or platelets fulfilling the 2016 revised WHO criteria for PV and ET, and out of these 411 should be evaluated regarding underlying myeloproliferative neoplasms. Unexplained thrombocytosis and secondary erythrocytosis were associated with the highest rate of recurrent event as well as the most inferior restricted mean survival time.

Conclusion: Elevated blood values are common in patients with thromboembolic event and the high risk of recurrent event and inferior restricted mean survival time in patients with unexplained thrombocytosis and secondary erythrocytosis implicates the importance of finding and managing the underlying condition.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2023. Vol. 110, nr 6, s. 608-617
Emneord [en]
essential thrombocythemia, polycythemia, polycythemia vera, thrombocytosis, thromboembolism
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-205189DOI: 10.1111/ejh.13938ISI: 000932888700001PubMedID: 36725666Scopus ID: 2-s2.0-85147986248OAI: oai:DiVA.org:umu-205189DiVA, id: diva2:1739922
Forskningsfinansiär
Norrbotten County CouncilTilgjengelig fra: 2023-02-28 Laget: 2023-02-28 Sist oppdatert: 2023-07-12bibliografisk kontrollert

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Enblom, AnneliHolmberg, HenrikLiljeholm, MariaSjälander, Anders

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