Umeå University's logo

umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Cognitive and mental fatigue in chronic pain: cognitive functions, emotional aspects, biomarkers and neuronal correlates - protocol for a descriptive cross-sectional study
Clinical Sciences, Karolinska Institutet, Stockholm, Sweden; Rehabilitation Medicine, Danderyd University Hospital, Stockholm, Sweden.
Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Rehabiliteringsmedicin. Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Rehabilitation Medicine, Danderyd University Hospital, Stockholm, Sweden; Clinical Sciences, Karolinska Institutet, Stockholm, Sweden.
Vise andre og tillknytning
2023 (engelsk)Inngår i: BMJ Open, E-ISSN 2044-6055, Vol. 13, nr 3, artikkel-id e068011Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

INTRODUCTION: Chronic pain (CP) is one of the most frequently presenting conditions in health care and many patients with CP report mental fatigue and a decline in cognitive functioning. However, the underlying mechanisms are still unknown.

METHODS AND ANALYSIS: This study protocol describes a cross-sectional study aimed at investigating the presence of self-rated mental fatigue, objectively measured cognitive fatigability and executive functions and their relation to other cognitive functions, inflammatory biomarkers and brain connectivity in patients with CP. We will control for pain-related factors such as pain intensity and secondary factors such as sleep disturbances and psychological well-being. Two hundred patients 18-50 years with CP will be recruited for a neuropsychological investigation at two outpatient study centres in Sweden. The patients are compared with 36 healthy controls. Of these, 36 patients and 36 controls will undergo blood sampling for inflammatory markers, and of these, 24 female patients and 22 female controls, between 18 and 45 years, will undergo an functional MRI investigation. Primary outcomes are cognitive fatigability, executive inhibition, imaging and inflammatory markers. Secondary outcomes include self-rated fatigue, verbal fluency and working memory. The study provides an approach to study fatigue and cognitive functions in CP with objective measurements and may demonstrate new models of fatigue and cognition in CP.

ETHICS AND DISSEMINATION: The study has been approved by the Swedish Ethics Review Board (Dnr 2018/424-31; 2018/1235-32; 2018/2395-32; 2019-66148; 2022-02838-02). All patients gave written informed consent to participate in the study. The study findings will be disseminated through publications in journals within the fields of pain, neuropsychology and rehabilitation. Results will be spread at relevant national and international conferences, meetings and expert forums. The results will be shared with user organisations and their members as well as relevant policymakers.

TRIAL REGISTRATION NUMBER: NCT05452915.

sted, utgiver, år, opplag, sider
2023. Vol. 13, nr 3, artikkel-id e068011
Emneord [en]
Neurology, Pain management, radiology and imaging
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-206529DOI: 10.1136/bmjopen-2022-068011ISI: 000991985100037PubMedID: 36990481Scopus ID: 2-s2.0-85151183871OAI: oai:DiVA.org:umu-206529DiVA, id: diva2:1749779
Tilgjengelig fra: 2023-04-11 Laget: 2023-04-11 Sist oppdatert: 2023-09-05bibliografisk kontrollert

Open Access i DiVA

fulltext(553 kB)102 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 553 kBChecksum SHA-512
e756a2cc9a37bbaf9c7f3910327c2c55cc7a02927a5657ef441208753c6b6cdcee6dc10d3cf5889dca8e4988da8e84a4a8544cd5d40a85f77deb5cfa8ecb8522
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMedScopus

Person

Berginström, NilsStålnacke, Britt-Marie

Søk i DiVA

Av forfatter/redaktør
Berginström, NilsStålnacke, Britt-Marie
Av organisasjonen
I samme tidsskrift
BMJ Open

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 102 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 350 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf