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Mitochondrial lipids in neurodegeneration
Institute of Molecular Biosciences, University of Graz, Graz, Austria.ORCID-id: 0000-0001-6571-2162
Institute of Molecular Biosciences, University of Graz, Graz, Austria.ORCID-id: 0000-0002-1241-162X
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Vise andre og tillknytning
2016 (engelsk)Inngår i: Cell and Tissue Research, ISSN 0302-766X, E-ISSN 1432-0878, Vol. 367, nr 1, s. 125-140Artikkel i tidsskrift (Annet vitenskapelig) Published
Abstract [en]

Mitochondrial dysfunction is a common feature of many neurodegenerative diseases, including proteinopathies such as Alzheimer’s or Parkinson’s disease, which are characterized by the deposition of aggregated proteins in the form of insoluble fibrils or plaques. The distinct molecular processes that eventually result in mitochondrial dysfunction during neurodegeneration are well studied but still not fully understood. However, defects in mitochondrial fission and fusion, mitophagy, oxidative phosphorylation and mitochondrial bioenergetics have been linked to cellular demise. These processes are influenced by the lipid environment within mitochondrial membranes as, besides membrane structure and curvature, recruitment and activity of different proteins also largely depend on the respective lipid composition. Hence, the interaction of neurotoxic proteins with certain lipids and the modification of lipid composition in different cell compartments, in particular mitochondria, decisively impact cell death associated with neurodegeneration. Here, we discuss the relevance of mitochondrial lipids in the pathological alterations that result in neuronal demise, focussing on proteinopathies.

sted, utgiver, år, opplag, sider
Springer, 2016. Vol. 367, nr 1, s. 125-140
Emneord [en]
Mitochondria, Lipids, Neurodegeneration, Mitochondrial dynamics, Mitochondria-associated membranes
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-215040DOI: 10.1007/s00441-016-2463-1ISI: 000391387300011PubMedID: 27449929Scopus ID: 2-s2.0-84979503766OAI: oai:DiVA.org:umu-215040DiVA, id: diva2:1802943
Forskningsfinansiär
Swedish Research Council, 2015-05468Tilgjengelig fra: 2023-10-06 Laget: 2023-10-06 Sist oppdatert: 2023-10-16bibliografisk kontrollert

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Kohler, AndreasKohler, Verena

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