Umeå University's logo

umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Characterising the covariance pattern between lifestyle factors and structural brain measures: a multivariable replication study of two independent ageing cohorts
Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark.
Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark; London Mathematical Laboratory, London, United Kingdom; Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark; Department of Neurology, Copenhagen University Hospital–Bispebjerg and Frederiksberg, Copenhagen, Denmark; Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital–Bispebjerg and Frederiksberg, Copenhagen, Denmark; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Vise andre og tillknytning
2023 (engelsk)Inngår i: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 131, s. 115-123Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Modifiable lifestyle factors have been shown to promote healthy brain ageing. However, studies have typically focused on a single factor at a time. Given that lifestyle factors do not occur in isolation, multivariable analyses provide a more realistic model of the lifestyle-brain relationship. Here, canonical correlation analyses (CCA) examined the relationship between nine lifestyle factors and seven MRI-derived indices of brain structure. The resulting covariance pattern was further explored with Bayesian regressions. CCA analyses were first conducted on a Danish cohort of older adults (n = 251) and then replicated in a British cohort (n = 668). In both cohorts, the latent factors of lifestyle and brain structure were positively correlated (UK: r =.37, p < 0.001; Denmark: r =.27, p < 0.001). In the cross-validation study, the correlation between lifestyle-brain latent factors was r =.10, p = 0.008. However, the pattern of associations differed between datasets. These findings suggest that baseline characterisation and tailoring towards the study sample may be beneficial for achieving targeted lifestyle interventions.

sted, utgiver, år, opplag, sider
Elsevier, 2023. Vol. 131, s. 115-123
Emneord [en]
Magnetic resonance imaging (MRI), Modifiable lifestyle factors, Old age, White matter hyperintensities
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-214977DOI: 10.1016/j.neurobiolaging.2023.07.023PubMedID: 37619515Scopus ID: 2-s2.0-85172425623OAI: oai:DiVA.org:umu-214977DiVA, id: diva2:1805009
Forskningsfinansiär
Novo Nordisk Foundation, NNF20OC0064869EU, Horizon 2020, 732592Tilgjengelig fra: 2023-10-16 Laget: 2023-10-16 Sist oppdatert: 2023-10-16bibliografisk kontrollert

Open Access i DiVA

fulltext(1568 kB)48 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 1568 kBChecksum SHA-512
555b37d0316b523139b68b0fcd1cb19d39e0de4fa1fb476327460b80ab59302914182eccdd32bd0eed23438a03bd29ebad0e5156468ada06033d825914790b60
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMedScopus

Person

Boraxbekk, Carl-Johan

Søk i DiVA

Av forfatter/redaktør
Boraxbekk, Carl-Johan
Av organisasjonen
I samme tidsskrift
Neurobiology of Aging

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 48 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 236 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf