Interactions between high seroreactivity to human herpes virus 6A and Epstein–Barr virus in MS development: a presymptomatic case–control studyVise andre og tillknytning
2024 (engelsk)Inngår i: Annals of Neurology, ISSN 0364-5134, E-ISSN 1531-8249, Vol. 96, nr 2, s. 302-305Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]
Synergistic interactions between human herpesvirus 6A (HHV-6A) and Epstein–Barr virus (EBV) are hypothesized in the etiopathogenesis of multiple sclerosis (MS). This study investigated if HHV-6A and EBV seroreactivities interact regarding the risk of developing MS. Antibodies against viral antigens were analyzed in biobank samples from 670 individuals who later developed MS and matched controls. Additive interactions were analyzed. A significant interaction between HHV-6A and EBNA-1 seroreactivities was observed in study participants above the median age of 24.9 years (attributable proportion due to interaction = 0.45). This finding supports the hypothesis that HHV-6A and EBV infections interact in MS development. ANN NEUROL 2024.
sted, utgiver, år, opplag, sider
John Wiley & Sons, 2024. Vol. 96, nr 2, s. 302-305
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-226943DOI: 10.1002/ana.27009ISI: 001243851600001PubMedID: 38860471Scopus ID: 2-s2.0-85195543916OAI: oai:DiVA.org:umu-226943DiVA, id: diva2:1876791
Forskningsfinansiär
Swedish Research Council, 2015-02419Visare NorrRegion Jämtland HärjedalenThe Swedish Brain FoundationEU, Horizon 2020, 7331612024-06-252024-06-252024-07-26bibliografisk kontrollert