In this study, the Homo-Separation of Variables method is introduced to find the exact solution of some coupled nonlinear partial differential equations. This analytical method is a new combination of two powerful and popular methods; namely the homotopy perturbation method (HPM) and the separation of variables method. The exact solution is constructed by choosing an appropriate initial approximation in addition to retaining only the first term of the series obtained by HPM. The proposed method is capable of reducing the computational load considerably when compared to other classical method.