In this study, we find the exact solution of certain partial differential equations (PDE) by proposingand using the Homo-Separation of Variables method. This novel analytical method is a combination of thehomotopy perturbation method (HPM) with the separation of variables method. The exact solutions are con-structed by choosing an appropriate initial approximation in addition to only one term of the series obtainedby HPM. The proposed method is introduced an efficient tool for solving a wide class of partial differentialequations. It is straight-forward, easy to understand and fast requiring low computational load.