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Nanoformulations deliver antibacterial agents synergistically. Positively charged Zn nanocomplexes were used as carriersfor chlorhexidine (CHX), developed using ionic liquids. The CHX-loaded Zn nanoparticles (CHZNPs) were characterisedthrough various techniques, including UV–visible Spectroscopy, TEM, FTIR, and Zeta potential analysis. The averagediameters of ZNPs and CHZNPs were 27.43 and 29.66 nm, respectively. CHZNPs consistently released CHX, enhancingits antibacterial effect. Tests against antibiotic-resistant Streptococcus pneumoniae strain 7465 revealed that CHZNPs significantlyreduced bacterial viability. At 100 μg/mL, CHX showed the highest antibacterial activity with the lowest minimalinhibitory concentration (MIC90) and minimal bactericidal concentration (MBC96) values, followed by CHZNPs, which hadlower MIC and MBC values. While ZNPs demonstrated some bactericidal effect at intermediate dosages (12 and 25 μg/mL), they could not fully inhibit bacterial growth. CHZNPs outperformed ZNPs across all concentrations, with an MIC of40 μg/mL compared to CHX’s 80 μg/mL. ZNPs showed no MIC at tested concentrations. Overall, CHZNPs significantlyreduced bacterial viability more effectively than CHX alone, highlighting their potential as a treatment for antibiotic-resistantS. pneumoniae infections.