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Constraint-induced movement therapy in stroke rehabilitation: impact on shoulder pain, motor function, balance and health-related quality of life
Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Rehabiliteringsmedicin.
2025 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)Alternativ tittel
Constraint-induced movement therapy i strokerehabilitering : effekter på axelsmärta, rörelseförmåga, balans och hälsorelaterad livskvalitet (svensk)
Abstract [en]

Background: Constraint-Induced Movement Therapy (CIMT) is a treatment modality originally intended for impaired arm and hand function following unilateral brain damage, such as stroke. Extensive research has shown that CIMT may effectively enhance upper-extremity motor function with a good carry-over effect to activity levels and the improvements sustained at long-term follow-up. However, the impact of CIMT on hemiplegic shoulder pain (HSP) and Health-related Quality of Life (HRQoL) has not been adequately investigated and clinical implementation of CIMT has thus far been limited. The CIMT concept has eventually been adapted to treat lower extremity deficits (LE-CIMT) focusing on gait and balance, however currently with limited evidence.

Aim: The overall aim of this thesis was to investigate treatment effects of CIMT in an outpatient clinical setting with focus on HSP, motor function, balance, leg muscle strength and HRQoL after stroke.

Methods: A longitudinal cohort study was conducted at a physiotherapy clinic in Stockholm between 2000 and 2018. The CIMT treatment was delivered to all participants and consisted of high-intensity, task-specific training, six hours per weekday for two consecutive weeks. Treatment focus was on either arm/hand or gait/balance. Assessments used were the Fugl-Meyer Assessment scale for scoring shoulder pain, goniometry for passive and active shoulder ROM and B. Lindmark Motor Assessment, Berg Balance Scale, Single-Leg-Stance, one Repetition Maximum in a leg press and Timed Up and Go. All assessments were carried out pre- and post-CIMT and at 3-month follow-up. Additionally, the short form-36 (SF-36) Health Survey was administered pre-CIMT and at 3-month follow-up to assess HRQoL.

Results: Study participants were middle-aged and in the subacute and chronic post-stroke phases. In the upper extremities cohort (221 participants, median age 56 years, 62% men) we found significantly reduced shoulder pain alongside improved motor function and active and passive range of motion. Additionally, positive impacts were found on HRQoL at 3-month follow-up post-CIMT. Results demonstrated overall improvements in physical domains, with women improving significantly more in physical domains and men in mental domains.

Regarding participants in lower extremity CIMT (147 participants, median age 53 years, 68% men), the intervention demonstrated enhanced balance, leg strength and dual-task ability. Leg strength improvements were greater in the affected leg, resulting in decreased leg strength asymmetry between affected and non-affected lower extremity. Furthermore, we showed positive impacts on HRQoL, revealing improvements in the Physical Function and Vitality domains after participation in lower extremity CIMT. Improvements after both CIMT and LE-CIMT were maintained at 3-month follow-up.

Conclusion: CIMT and LE-CIMT are clinically applicable treatment modalities in an outpatient clinical setting with positive impacts on HSP, motor function, balance and leg strength as well as improved self-assessed health-related quality of life among predominantly middle-aged individuals in a chronic stage post-stroke.

sted, utgiver, år, opplag, sider
Umeå: Umeå University, 2025. , s. 64
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 2398
Emneord [en]
Stroke, Rehabilitation, Constraint-Induced Movement Therapy, Shoulder Pain, Motor function, Balance, Helath-Related Quality of Life
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-246151ISBN: 978-91-8070-855-5 (tryckt)ISBN: 978-91-8070-856-2 (digital)OAI: oai:DiVA.org:umu-246151DiVA, id: diva2:2011455
Disputas
2025-11-28, Lilla Hörsalen, KBC-huset, plan 3, Umeå universitet, Umeå, 09:00 (svensk)
Opponent
Veileder
Tilgjengelig fra: 2025-11-07 Laget: 2025-11-04 Sist oppdatert: 2025-11-07bibliografisk kontrollert
Delarbeid
1. Constraint-induced movement therapy reduced shoulder pain and improved function in subacute and chronic stroke: a cohort study
Åpne denne publikasjonen i ny fane eller vindu >>Constraint-induced movement therapy reduced shoulder pain and improved function in subacute and chronic stroke: a cohort study
Vise andre…
2025 (engelsk)Inngår i: Frontiers in Neurology, E-ISSN 1664-2295, Vol. 16, artikkel-id 1639840Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Introduction: The objective of this study was to evaluate the effects of Constraint-Induced Movement Therapy (CIMT) on hemiplegic shoulder pain (HSP), shoulder range of motion (ROM) and upper extremity motor function in stroke patients.

Methods: This longitudinal intervention cohort study was performed in an outpatient clinic without a control group. Participants underwent individually tailored CIMT with a patient therapist ratio of 4:1 for 6 h/day, 5 days/week for 2 consecutive weeks, including daily shoulder strength and joint motion training. A total of 221 (101 with and 120 without pre-CIMT HSP) middle-aged (median 54 years) persons at sub-acute or chronic phases after stroke were included in the study. The Fugl-Meyer Assessment (FMA) subscale for pain was used for defining and scoring HSP at passive motion (sum of four directions of movement, maximum 8 points indicating no pain). Passive and active shoulder ROM (sum of flexion and abduction) were assessed. Upper extremity motor function was assessed with B. Lindmark Motor Assessment. Assessments were done pre- and post-CIMT and at 3-month follow-up. Comparisons were stratified by subgroups with- and without HSP.

Results: In the subgroup with pre-CIMT HSP, median HSP score at passive movement was reduced (FMA shoulder pain score increased) from pre- to post-CIMT from 5 points to 7 points post-CIMT, (p < 0.001, Effect size (ES) 0.68). Median active ROM increased from 230° to 308° (p < 0.001, ES 0.72) and median passive ROM increased from 350° to 360° (p < 0.001, ES 0.44). Median motor function improved from 42 to 49 points (p < 0.001, ES 0.92). In the subgroup without pre-CIMT HSP no statistically significant increase of HSP was seen and no clinically significant changes observed for active or passive ROM after CIMT. Median motor function improved from 52 to 56 points (p < 0.001, ES 0.71). All improvements persisted at 3-month follow-up.

Conclusion: CIMT in an outpatient clinical setting may be a feasible treatment to decrease HSP and to improve shoulder ROM and upper extremity motor function among middle-aged persons in the subacute and chronic phases after stroke. Results need to be confirmed in an RCT setting.

sted, utgiver, år, opplag, sider
Frontiers Media S.A., 2025
Emneord
constraint-induced movement therapy, motor function, range of motion (ROM), shoulder pain, shoulder range of motion, stroke rehabilitation, upper extremity motor function
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-244876 (URN)10.3389/fneur.2025.1639840 (DOI)001575085700001 ()40979203 (PubMedID)2-s2.0-105016569392 (Scopus ID)
Forskningsfinansiär
Region VästerbottenUmeå UniversityThe Swedish Stroke Association
Tilgjengelig fra: 2025-10-02 Laget: 2025-10-02 Sist oppdatert: 2025-11-04bibliografisk kontrollert
2. Improved health-related quality of life after constraint-induced movement therapy in middle-aged adults with stroke: a longitudinal cohort study
Åpne denne publikasjonen i ny fane eller vindu >>Improved health-related quality of life after constraint-induced movement therapy in middle-aged adults with stroke: a longitudinal cohort study
Vise andre…
(engelsk)Manuskript (preprint) (Annet vitenskapelig)
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-246149 (URN)
Tilgjengelig fra: 2025-11-04 Laget: 2025-11-04 Sist oppdatert: 2025-11-04bibliografisk kontrollert
3. Positive effects of lower extremity constraint-induced movement therapy on balance, leg strength and dual-task ability in stroke patients: a longitudinal cohort study
Åpne denne publikasjonen i ny fane eller vindu >>Positive effects of lower extremity constraint-induced movement therapy on balance, leg strength and dual-task ability in stroke patients: a longitudinal cohort study
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2024 (engelsk)Inngår i: Journal of Rehabilitation Medicine, ISSN 1650-1977, E-ISSN 1651-2081, Vol. 56, artikkel-id jrm24168Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective: To investigate whether high-intensity lower extremity constraint-induced movement therapy can improve balance, leg strength, and dual-task ability.

Design: A longitudinal cohort study in a real-world outpatient clinic.

Patients: 147 community-dwelling participants in the subacute and chronic poststroke phases.

Methods: Participants received lower extremity constraint-induced movement therapy for 6 hours/day during 2 consecutive weeks, including balance, strength, and functional training. The Berg Balance Scale (BBS), Single-Leg-Stance (SLS) bilaterally, one Repetition Maximum (1RM) in a leg press, symmetry of leg strength (Diff-1RM), Timed Up and Go (TUG), and the TUG Manual test were assessed before, after, and 3 months after lower extremity constraint-induced movement therapy.

Results: Compared with preintervention data, statistically significant improvements after lower extremity constraint-induced movement therapy (p < 0.001) were demonstrated for balance with an absolute value in BBS at 1.9 points (effect size 0.38) and SLS at 2.4 s (effect size 0.24), and for leg strength at 10.2 kg (effect size 0.54) for the affected leg. Diff 1RM decreased significantly at 5.8 kg (effect size 0.39) and improvements on dual-task ability at 2.7 s were significant (effect size 0.14). The effects persisted at the 3-month follow-up.

Conclusions: High-intensity lower extremity constraint-induced movement therapy may be a feasible treatment option for middle-aged stroke patients to affect balance, leg strength, and dual-task ability positively in an out-patient clinical setting.

sted, utgiver, år, opplag, sider
MJS Publishing, 2024
Emneord
balance, constraint-induced movement therapy, dual-task, high-intensity training, lower extremity, physical therapy, strength training, stroke rehabilitation
HSV kategori
Forskningsprogram
fysioterapi
Identifikatorer
urn:nbn:se:umu:diva-230509 (URN)10.2340/jrm.v56.24168 (DOI)001329749100001 ()39360525 (PubMedID)2-s2.0-85206910647 (Scopus ID)
Forskningsfinansiär
Region VästerbottenThe Swedish Stroke Association
Tilgjengelig fra: 2024-10-04 Laget: 2024-10-04 Sist oppdatert: 2025-11-04bibliografisk kontrollert
4. Improved health-related quality of life among individuals with stroke following lower-extremity constraint-induced movement therapy: a longitudinal cohort study
Åpne denne publikasjonen i ny fane eller vindu >>Improved health-related quality of life among individuals with stroke following lower-extremity constraint-induced movement therapy: a longitudinal cohort study
Vise andre…
(engelsk)Manuskript (preprint) (Annet vitenskapelig)
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-246150 (URN)
Tilgjengelig fra: 2025-11-04 Laget: 2025-11-04 Sist oppdatert: 2025-11-05bibliografisk kontrollert

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