Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Quantitative Comparison Of Vesicular Glutamate Transporters in rat Deep Cerebellar Nuclei
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB). Department of Cognitive Neurology, HIH for Clinical Brain Research, Tübingen, Germany.ORCID-id: 0000-0001-9194-9905
2018 (Engelska)Ingår i: Neuroscience, ISSN 0306-4522, E-ISSN 1873-7544, Vol. 376, s. 152-161Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The excitatory synapses of the rat deep cerebellar nuclei (DCN) were quantitatively analyzed by vesicular glutamate transporter 1 and 2 (vGluT1 and vGluT2) immunolabeling. We calculated the number and sizes of the labeled boutons and compared them between lateral/dentate nucleus (LN/DN), posterior interposed nucleus (PIN), anterior interposed nucleus (AIN), and medial nucleus (MN). The density of vGluT1+ boutons differs significantly within these nuclei. In contrast, the vGluT2+ bouton density is more similar between different nuclei. The phylogenetically newer DCN (LN/DN and PIN) have a 39% higher density of vGluT1+ boutons than the phylogenetically older DCN (AIN and MN). The volume of vGluT1+ boutons does not differ between the DCN, however the average volume of vGluT2+ boutons is larger in MN. In summary, our current results confirm and extend our previous findings showing that the increase in dendritic and axonal wiring in phylogenetically newer DCN is associated with an increase in vGluT1+ bouton density.

Ort, förlag, år, upplaga, sidor
2018. Vol. 376, s. 152-161
Nyckelord [en]
vesicular glutamate transporter, quantitative analysis, bouton density, bouton size, deep cerebellar nuclei
Nationell ämneskategori
Neurovetenskaper
Identifikatorer
URN: urn:nbn:se:umu:diva-146035DOI: 10.1016/j.neuroscience.2018.02.020ISI: 000427828400013PubMedID: 29462701Scopus ID: 2-s2.0-85042858919OAI: oai:DiVA.org:umu-146035DiVA, id: diva2:1193438
Tillgänglig från: 2018-03-27 Skapad: 2018-03-27 Senast uppdaterad: 2023-03-24Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Person

Sultan, Fahad

Sök vidare i DiVA

Av författaren/redaktören
Sultan, Fahad
Av organisationen
Institutionen för integrativ medicinsk biologi (IMB)
I samma tidskrift
Neuroscience
Neurovetenskaper

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 292 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf