Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s diseaseCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
Center for Vital Longevity, University of Texas, TX, Dallas, United States.
MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom.
MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom.
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
Center for Vital Longevity, University of Texas, TX, Dallas, United States.
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB). Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI).
Center for Vital Longevity, University of Texas, TX, Dallas, United States.
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
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2021 (Engelska)Ingår i: Nature Communications, E-ISSN 2041-1723, Vol. 12, nr 1, artikel-id 721Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
Aging and Alzheimer’s disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown whether continuous age- and AD-related cortical degradation alters cortical asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order cortical regions exhibiting pronounced asymmetry at age ~20 also show progressive asymmetry-loss across the adult lifespan. Hence, accelerated thinning of the (previously) thicker homotopic hemisphere is a feature of aging. This organizational principle showed high consistency across cohorts in the Lifebrain consortium, and both the topological patterns and temporal dynamics of asymmetry-loss were markedly similar across replicating samples. Asymmetry-change was further accelerated in AD. Results suggest a system-wide dedifferentiation of the adaptive asymmetric organization of heteromodal cortex in aging and AD.
Ort, förlag, år, upplaga, sidor
Nature Research , 2021. Vol. 12, nr 1, artikel-id 721
Nationell ämneskategori
Neurovetenskaper
Identifikatorer
URN: urn:nbn:se:umu:diva-180521DOI: 10.1038/s41467-021-21057-yISI: 000616941000002PubMedID: 33526780Scopus ID: 2-s2.0-85100257409OAI: oai:DiVA.org:umu-180521DiVA, id: diva2:1531059
Forskningsfinansiär
EU, Horisont 2020, 732592Norges forskningsråd, 249931
Anmärkning
Correction: Roe, J.M., Vidal-Piñeiro, D., Sørensen, Ø. et al. Author Correction: Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease. Nat Commun 13, 834 (2022). DOI: 10.1038/s41467-022-28514-2
2021-02-252021-02-252023-09-05Bibliografiskt granskad