Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Serological Evidence of Exposure to Onyong-Nyong and Chikungunya Viruses in Febrile Patients of Rural Taita-Taveta County and Urban Kibera Informal Settlement in Nairobi, Kenya
KAVI Institute of Clinical Research, University of Nairobi, POB 19676, Nairobi, Kenya; Department of Medical Microbiology, University of Nairobi, POB 19676, Nairobi, Kenya.
Department of Virology, University of Helsinki, Helsinki, Finland; Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
Department of Virology, University of Helsinki, Helsinki, Finland; HUS Diagnostic Center, HUSLAB, Virology and Immunology, Helsinki University Hospital, Helsinki, Finland.
Department of Virology, University of Helsinki, Helsinki, Finland; Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland; Department of Geosciences and Geography, University of Helsinki, Helsinki, Finland.
Visa övriga samt affilieringar
2022 (Engelska)Ingår i: Viruses, E-ISSN 1999-4915, Vol. 14, nr 6, artikel-id 1286Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Several alphaviruses, such as chikungunya (CHIKV) and Onyong-nyong (ONNV), are endemic in Kenya and often cause outbreaks in different parts of the country. We assessed the seroprevalence of alphaviruses in patients with acute febrile illness in two geographically distant areas in Kenya with no previous record of alphavirus outbreaks. Blood samples were collected from febrile patients in health facilities located in the rural Taita-Taveta County in 2016 and urban Kibera informal settlement in Nairobi in 2017 and tested for CHIKV IgG and IgM antibodies using an in-house immunofluorescence assay (IFA) and a commercial ELISA test, respectively. A subset of CHIKV IgG or IgM antibody-positive samples were further analyzed using plaque reduction neutralization tests (PRNT) for CHIKV, ONNV, and Sindbis virus. Out of 537 patients, 4 (0.7%) and 28 (5.2%) had alphavirus IgM and IgG antibodies, respectively, confirmed on PRNT. We show evidence of previous and current exposure to alphaviruses based on serological testing in areas with no recorded history of outbreaks.

Ort, förlag, år, upplaga, sidor
MDPI, 2022. Vol. 14, nr 6, artikel-id 1286
Nyckelord [en]
alphavirus, arbovirus, chikungunya, ELISA, febrile illness, immunofluorescence, neutralization, Onyong-nyong, seroprevalence
Nationell ämneskategori
Infektionsmedicin Mikrobiologi inom det medicinska området
Identifikatorer
URN: urn:nbn:se:umu:diva-203180DOI: 10.3390/v14061286ISI: 000818334100001PubMedID: 35746757Scopus ID: 2-s2.0-85132365824OAI: oai:DiVA.org:umu-203180DiVA, id: diva2:1727454
Forskningsfinansiär
Finlands AkademiTillgänglig från: 2023-01-16 Skapad: 2023-01-16 Senast uppdaterad: 2024-01-17Bibliografiskt granskad

Open Access i DiVA

fulltext(1702 kB)104 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 1702 kBChecksumma SHA-512
7de8d46e022cf41a487e985e693ebcb7e4d5d9d30815ccc4587bcc64228a0e347be33d36e819beb0c5c6a579cf3d14f8a5c4555f92e6ddb18708b355c13207a6
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMedScopus

Person

Yong-Dae, GwonEvander, Magnus

Sök vidare i DiVA

Av författaren/redaktören
Yong-Dae, GwonEvander, Magnus
Av organisationen
Institutionen för klinisk mikrobiologi
I samma tidskrift
Viruses
InfektionsmedicinMikrobiologi inom det medicinska området

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 104 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 143 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf