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Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis: Results from SCAPIS
Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Medicine Geriatrics and Emergency Medicine, Sahlgrenska University Hospital Östra Hospital, Gothenburg, Sweden.
Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden; Department of Radiology, Capio S:t Göran Hospital, Stockholm, Sweden.
Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
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2023 (Engelska)Ingår i: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 373, s. 46-54Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background and aims: Elevated body weight in adolescence is associated with early cardiovascular disease, but whether this association is traceable to weight in early adulthood, weight in midlife or to weight gain is not known. The aim of this study is to assess the risk of midlife coronary atherosclerosis being associated with body weight at age 20, body weight in midlife and body weight change.

Methods: We used data from 25,181 participants with no previous myocardial infarction or cardiac procedure in the Swedish CArdioPulmonary bioImage Study (SCAPIS, mean age 57 years, 51% women). Data on coronary atherosclerosis, self-reported body weight at age 20 and measured midlife weight were recorded together with potential confounders and mediators. Coronary atherosclerosis was assessed using coronary computed tomography angiography (CCTA) and expressed as segment involvement score (SIS).

Results: The probability of having coronary atherosclerosis was markedly higher with increasing weight at age 20 and with mid-life weight (p < 0.001 for both sexes). However, weight increase from age 20 until mid-life was only modestly associated with coronary atherosclerosis. The association between weight gain and coronary atherosclerosis was mainly seen in men. However, no significant sex difference could be detected when adjusting for the 10-year delay in disease development in women.

Conclusions: Similar in men and women, weight at age 20 and weight in midlife are strongly related to coronary atherosclerosis while weight increase from age 20 until midlife is only modestly related to coronary atherosclerosis.

Ort, förlag, år, upplaga, sidor
Elsevier, 2023. Vol. 373, s. 46-54
Nyckelord [en]
Coronary artery calcium score, Midlife, Sex, Weight, Weight gain
Nationell ämneskategori
Kardiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-205473DOI: 10.1016/j.atherosclerosis.2023.01.024ISI: 001010662800001PubMedID: 36813601Scopus ID: 2-s2.0-85148722883OAI: oai:DiVA.org:umu-205473DiVA, id: diva2:1744107
Forskningsfinansiär
Hjärt-LungfondenKnut och Alice Wallenbergs StiftelseVetenskapsrådetVinnovaGöteborgs universitetKarolinska InstitutetLinköpings universitetLunds universitetUmeå universitetUppsala universitetHjärt-Lungfonden, 20180324Vetenskapsrådet, 2019–01140Vetenskapsrådet, 2018–02527AFA Försäkring, 160334Tillgänglig från: 2023-03-17 Skapad: 2023-03-17 Senast uppdaterad: 2023-09-05Bibliografiskt granskad

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Lilja, MikaelSandström, AnetteSkoglund Larsson, LinnSöderberg, Stefan

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