Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Prediagnostic markers of insulin resistance and prostate cancer risk and death: a pooled study
Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Department of Translational Medicine, Lund University, Malmö, Sweden; Institute of Medical Statistics and Informatics, Medical University of Innsbruck, Innsbruck, Austria.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.ORCID-id: 0000-0001-6808-4405
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Visa övriga samt affilieringar
2023 (Engelska)Ingår i: Cancer Medicine, E-ISSN 2045-7634, Vol. 12, nr 12, s. 13732-13744Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Insulin resistance has been shown to be related to a higher risk of several cancers, but the association with prostate cancer (PCa) has been inconsistent.

Methods: We investigated prediagnostic markers of insulin resistance in men in four cohorts in Sweden, in relation to PCa risk (total, non-aggressive and aggressive) and PCa death using multivariable-adjusted Cox regression. The number of men, PCa cases and PCa deaths was up to 66,668, 3940 and 473 for plasma glucose and the triglyceride-glucose (TyG) index, and up to 3898, 586 and 102 for plasma insulin, glycated haemoglobin (HbA1c) and leptin.

Results: Higher HbA1c was related to a lower risk of non-aggressive PCa but no significant associations were found for insulin resistance markers with the risk of aggressive or total PCa. In PCa cases, higher glucose and TyG index were related to a higher risk of PCa death (hazard ratio [HR] per higher standard deviation, 1.22, 95% CI 1.00–1.49 and 1.24, 95% CI 1.00–1.55), which further increased when restricting the analyses to glucose and TyG index measures taken <10 years before the PCa diagnosis (HR, 1.70, 95% CI 1.09–2.70 and 1.66, 95% CI 1.12–2.51). No associations were observed for other markers in relation to PCa death.

Conclusions: The results of this study showed no associations of insulin resistance markers with the risk of clinically relevant PCa, but higher glucose and TyG index were associated with poorer survival from PCa. The lack of association for other insulin resistance markers may be due to their smaller sample size.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2023. Vol. 12, nr 12, s. 13732-13744
Nyckelord [en]
insulin resistance, prospective studies, prostatic neoplasms
Nationell ämneskategori
Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:umu:diva-208261DOI: 10.1002/cam4.6004ISI: 000979235300001PubMedID: 37102250Scopus ID: 2-s2.0-85156191845OAI: oai:DiVA.org:umu-208261DiVA, id: diva2:1758251
Forskningsfinansiär
Cancerfonden, 2017/475Cancerfonden, 2017/1019Cancerfonden, 201,033 PjFVetenskapsrådet, 2018-02825Vetenskapsrådet, 2017‐00650Crafoordska stiftelsen, 20200546ProstatacancerförbundetTillgänglig från: 2023-05-22 Skapad: 2023-05-22 Senast uppdaterad: 2024-01-17Bibliografiskt granskad

Open Access i DiVA

fulltext(421 kB)36 nedladdningar
Filinformation
Filnamn FULLTEXT02.pdfFilstorlek 421 kBChecksumma SHA-512
c8968a70dddcc4e23e94812716d1873ea06f92d1e261b3ed5d453b64e30884dbdfffe5cfff510679f2c1e0aef0e56c88480bb02c34c8fd2bb3642ebcaabafc7c
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMedScopus

Person

Häggström, Christel

Sök vidare i DiVA

Av författaren/redaktören
Häggström, Christel
Av organisationen
Institutionen för folkhälsa och klinisk medicin
I samma tidskrift
Cancer Medicine
Cancer och onkologi

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 68 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 274 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf