Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Mitochondrial lipids in neurodegeneration
Institute of Molecular Biosciences, University of Graz, Graz, Austria.ORCID-id: 0000-0001-6571-2162
Institute of Molecular Biosciences, University of Graz, Graz, Austria.ORCID-id: 0000-0002-1241-162X
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Visa övriga samt affilieringar
2016 (Engelska)Ingår i: Cell and Tissue Research, ISSN 0302-766X, E-ISSN 1432-0878, Vol. 367, nr 1, s. 125-140Artikel i tidskrift (Övrigt vetenskapligt) Published
Abstract [en]

Mitochondrial dysfunction is a common feature of many neurodegenerative diseases, including proteinopathies such as Alzheimer’s or Parkinson’s disease, which are characterized by the deposition of aggregated proteins in the form of insoluble fibrils or plaques. The distinct molecular processes that eventually result in mitochondrial dysfunction during neurodegeneration are well studied but still not fully understood. However, defects in mitochondrial fission and fusion, mitophagy, oxidative phosphorylation and mitochondrial bioenergetics have been linked to cellular demise. These processes are influenced by the lipid environment within mitochondrial membranes as, besides membrane structure and curvature, recruitment and activity of different proteins also largely depend on the respective lipid composition. Hence, the interaction of neurotoxic proteins with certain lipids and the modification of lipid composition in different cell compartments, in particular mitochondria, decisively impact cell death associated with neurodegeneration. Here, we discuss the relevance of mitochondrial lipids in the pathological alterations that result in neuronal demise, focussing on proteinopathies.

Ort, förlag, år, upplaga, sidor
Springer, 2016. Vol. 367, nr 1, s. 125-140
Nyckelord [en]
Mitochondria, Lipids, Neurodegeneration, Mitochondrial dynamics, Mitochondria-associated membranes
Nationell ämneskategori
Cellbiologi Biokemi och molekylärbiologi Neurovetenskaper
Identifikatorer
URN: urn:nbn:se:umu:diva-215040DOI: 10.1007/s00441-016-2463-1ISI: 000391387300011PubMedID: 27449929Scopus ID: 2-s2.0-84979503766OAI: oai:DiVA.org:umu-215040DiVA, id: diva2:1802943
Forskningsfinansiär
Vetenskapsrådet, 2015-05468Tillgänglig från: 2023-10-06 Skapad: 2023-10-06 Senast uppdaterad: 2023-10-16Bibliografiskt granskad

Open Access i DiVA

fulltext(2158 kB)31 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 2158 kBChecksumma SHA-512
7193e046f32315206f1d2d5da1904296d2f9bcfa7b5364c38b9e7d501757b2818d8247f3460dc4106fd6072f6b7206751f5a3d4834b0f7728196106c44e2f9b5
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMedScopus

Person

Kohler, AndreasKohler, Verena

Sök vidare i DiVA

Av författaren/redaktören
Kohler, AndreasKohler, Verena
I samma tidskrift
Cell and Tissue Research
CellbiologiBiokemi och molekylärbiologiNeurovetenskaper

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 31 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 121 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf