Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Mitral E-wave to stroke volume ratio displays stronger diagnostic performance to identify elevated left ventricular filling pressures than mitral E/e' during passive leg lift: a cross-sectional study employing simultaneous echocardiography and catheterization
Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Klinisk fysiologi.ORCID-id: 0000-0002-8192-9166
2024 (Engelska)Ingår i: Echocardiography, ISSN 0742-2822, E-ISSN 1540-8175, Vol. 41, nr 2, artikel-id e15756Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Elevated filling pressure is a hallmark of heart failure (HF) and portends poor prognosis. Accurate diagnosis is challenging, given that patients with normal filling pressure at rest develop disproportionate elevation with sudden preload increase. We aimed to test the accuracy of the ratio between mitral inflow velocity (E) and left ventricular stroke volume (SV) to identify patients with elevated filling pressure with passive leg lifting (PLL) and compare this with other echocardiographic surrogates of filling pressure.

Methods: Doppler echocardiography and right heart catheterization (RHC) were simultaneously performed in 37 patients (11 males, mean age 67 ± 12 years) with exertional dyspnea. Twenty-six healthy controls (14 males, mean age 60 ± 12 years) were added as reference. SV, cardiac output (CO), tricuspid regurgitation peak gradient (TRG), mitral E-wave (E) and early myocardial velocity (e') were obtained at rest and with PLL. E/SV, E/CO and E/e' were calculated and correlated with invasive pulmonary capillary wedge pressures (PCWP) with PLL.

Results: During PLL, E/SV (AUC = 0.94) displayed stronger diagnostic ability to identify PCWP >15 mmHg than E/e' (AUC = 0.81), mitral E/A ratio (0.76) and resting invasive PCWP (0.84). An E/SV cutoff of >1.0 showed 88% sensitivity and 75% specificity to identify elevated PCWP. Further, 10 patients (27%) were reassigned during PLL from normal to postcapillary pulmonary hypertension (postCPH), and 6 patients (16%) switched diagnosis from precapillary PH (preCPH) to postCPH.

Conclusion: The novel E/SV ratio identifies patients with elevated PCWP with PLL and displays stronger diagnostic performance than routinely utilized echocardiographic measures such as E/e' in addition to resting, catheterization derived PCWP.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2024. Vol. 41, nr 2, artikel-id e15756
Nyckelord [en]
Doppler, filling pressure, heart failure, passive leg lifting, pulmonary hypertension
Nationell ämneskategori
Kardiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-221481DOI: 10.1111/echo.15756PubMedID: 38400581Scopus ID: 2-s2.0-85184507860OAI: oai:DiVA.org:umu-221481DiVA, id: diva2:1840576
Forskningsfinansiär
Vetenskapsrådet, 2019-01338Vetenskapsrådet, 2022-01254Hjärt-Lungfonden, 20160787Hjärt-Lungfonden, 20200160Tillgänglig från: 2024-02-26 Skapad: 2024-02-26 Senast uppdaterad: 2024-03-07Bibliografiskt granskad

Open Access i DiVA

fulltext(692 kB)467 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 692 kBChecksumma SHA-512
69f3e33a874bd86751126686b93183b0fd87bbf9d6be1e8ee12e27df2cf5a1b9fe15c77716179a2cfff8d7dab738528cd4798cf92f99ffd5f831c98a76e53fbf
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMedScopus

Person

Lindqvist, Per

Sök vidare i DiVA

Av författaren/redaktören
Lindqvist, Per
Av organisationen
Klinisk fysiologi
I samma tidskrift
Echocardiography
Kardiologi

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 467 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 571 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf