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Machine learning is increasingly used as a computing paradigm in cartographic research. In this extended editorial, we provide some background of the papers in the CaGIS special issue Machine Learning in Cartography with a special focus on pattern recognition in maps, cartographic generalization, style transfer, and map labeling. In addition, the paper includes a discussion about map encodings for machine learning applications and the possible need for explicit cartographic knowledge and procedural modeling in cartographic machine learning models.