Over the past century, the Earth’s climate has undergone rapid and unprecedented changes, manifested in a noticeable increase in average global temperature. This has led to shifts in precipitation patterns, increased frequency of extreme weather events (e.g. hurricanes, heatwaves, droughts and floods), alterations in ecosystems, and rising sea levels, impacting both natural environments and human societies, health and wellbeing. Without deep and urgent emission cuts and effective adaptation, the toll of climate change on human health and wellbeing is likely to grow. Here, we address the complex relationship between climate change and health, and discuss ways forward for transdisciplinary research and collaboration that can motivate more ambitious mitigation policies and help develop solutions to adapt to the crisis.