Umeå University's logo

umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Impact of Amyotrophic Lateral Sclerosis on Slow Tonic Myofiber Composition in Human Extraocular Muscles
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB). Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Oftalmiatrik.ORCID-id: 0000-0003-2369-4319
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB).
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
Vise andre og tillknytning
2017 (engelsk)Inngår i: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 58, nr 9, s. 3708-3715Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

PURPOSE. To analyze the proportion and cross-sectional area of myofibers containing myosin heavy chain slow-twitch (MyHCI) and myosin heavy chain slow tonic (MyHCsto) in extraocular muscles of autopsied amyotrophic lateral sclerosis (ALS) patients with either spinal or bulbar site of disease onset. METHODS. Whole-muscle cross sections from the middle portion of the medial rectus were labeled with antibodies against MyHCI or MyHCsto and laminin. Myofibers labeled with the MyHC antibodies (MyHCI+sto) and the total number of myofibers were quantified in the orbital and global layer of 6 control individuals and 18 ALS patients. The cross-sectional area of myofibers labeled for either MyHC was quantified in 130 to 472 fibers/individual in the orbital and in 180 to 573 fibers/individual in the global layer of each specimen. RESULTS. The proportion of MyHCI+sto myofibers was significantly smaller in the orbital and global layer of ALS compared to control individuals. MyHCI+sto myofibers were significantly smaller in the global layer than in the orbital layer of ALS, whereas they were of similar size in control subjects. The decreased proportion of MyHCI+sto fibers correlated significantly with the age of death, but not disease duration, in patients who had the bulbar-onset variant of ALS but not in patients with spinal variant. CONCLUSIONS. ALS, regardless of site of onset, involves a loss of myofibers containing MyHCI+sto. Only in bulbar-onset cases did aging seem to play a role in the pathophysiological processes underlying the loss of MyHCI+sto fibers.

sted, utgiver, år, opplag, sider
ASSOC RESEARCH VISION OPHTHALMOLOGY INC , 2017. Vol. 58, nr 9, s. 3708-3715
Emneord [en]
amyotrophic lateral sclerosis, extraocular muscles, MyH14, slow tonic, muscle fibers
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-140482DOI: 10.1167/iovs.17-22098ISI: 000410931200051PubMedID: 28738414Scopus ID: 2-s2.0-85026313703OAI: oai:DiVA.org:umu-140482DiVA, id: diva2:1150913
Tilgjengelig fra: 2017-10-20 Laget: 2017-10-20 Sist oppdatert: 2023-06-26bibliografisk kontrollert

Open Access i DiVA

fulltext(744 kB)408 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 744 kBChecksum SHA-512
034e5feedf77ad4d5aa5a39f077c7eb5eb6a93536aab6abaf455cb5a4800c19561e2aaca65c2d6ec39d5e36f18b6e935ec3f8c06c9052d63defc3b64dc7c4eb0
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMedScopus

Person

Tjust, Anton E.Danielsson, AdamAndersen, Peter M.Brännstrom, ThomasPedrosa-Domellöf, Fatima

Søk i DiVA

Av forfatter/redaktør
Tjust, Anton E.Danielsson, AdamAndersen, Peter M.Brännstrom, ThomasPedrosa-Domellöf, Fatima
Av organisasjonen
I samme tidsskrift
Investigative Ophthalmology and Visual Science

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 408 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 809 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf