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Keeping in touch with the membrane; protein- and lipid-mediated confinement of caveolae to the cell surface
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Department of Pharmacy, Uppsala University, BMC P.O. Box 580, SE-751 23 Uppsala, Sweden.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).ORCID iD: 0000-0001-9104-724X
2020 (English)In: Biochemical Society Transactions, ISSN 0300-5127, E-ISSN 1470-8752, Vol. 48, p. 155-163Article, review/survey (Refereed) Published
Abstract [en]

Caveolae are small Omega-shaped invaginations of the plasma membrane that play important roles in mechanosensing, lipid homeostasis and signaling. Their typical morphology is characterized by a membrane funnel connecting a spherical bulb to the membrane. Membrane funnels (commonly known as necks and pores) are frequently observed as transient states during fusion and fission of membrane vesicles in cells. However, caveolae display atypical dynamics where the membrane funnel can be stabilized over an extended period of time, resulting in cell surface constrained caveolae. In addition, caveolae are also known to undergo flattening as well as short-range cycles of fission and fusion with the membrane, requiring that the membrane funnel closes or opens up, respectively. This mini-review considers the transition between these different states and highlights the role of the protein and lipid components that have been identified to control the balance between surface association and release of caveolae.

Place, publisher, year, edition, pages
PORTLAND PRESS LTD , 2020. Vol. 48, p. 155-163
Keywords [en]
caveolae, caveolin, cholesterol, dynamics, EHD2, pacsin2
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-169355DOI: 10.1042/BST20190386ISI: 000518382800015PubMedID: 32049332Scopus ID: 2-s2.0-85081069553OAI: oai:DiVA.org:umu-169355DiVA, id: diva2:1422391
Available from: 2020-04-07 Created: 2020-04-07 Last updated: 2023-03-23Bibliographically approved

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Hubert, MadlenLarsson, ElinLundmark, Richard

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