Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
C-reactive Protein and Future Risk of Clinical and Molecular Subtypes of Colorectal Cancer
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.ORCID iD: 0000-0002-2974-2003
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Show others and affiliations
2020 (English)In: Cancer Epidemiology, Biomarkers and Prevention, ISSN 1055-9965, E-ISSN 1538-7755, Vol. 29, no 7, p. 1482-1491Article in journal (Refereed) Published
Abstract [en]

Background: Inflammation has been implicated in colorectal cancer etiology, but the relationship between C-reactive protein (CRP) and colorectal cancer risk is unclear. We aimed to investigate the association between prediagnostic plasma CRP concentrations and the risk of clinical and molecular colorectal cancer subtypes.

Methods: We used prospectively collected samples from 1,010 matched colorectal cancer case-control pairs from two population-based cohorts in Northern Sweden, including 259 with repeated samples. Conditional logistic regression and linear mixed models were used to estimate relative risks of colorectal cancer, including subtypes based on BRAF and KRAS mutations, microsatellite instability status, tumor location, stage, lag time, and (using unconditional logistic regression) body mass index.

Results: CRP was not associated with colorectal cancer risk, regardless of clinical or molecular colorectal cancer subtype. For participants with advanced tumors and blood samples <5 years before diagnosis, CRP was associated with higher risk [OR per 1 unit increase in natural logarithm (In) transformed CRP, 1.32; 95% confidence interval (CI), 1.01-1.73]. CRP levels increased over time, but average time trajectories were similar for cases and controls (P-interaction = 0.19).

Conclusions: Our results do not support intertumoral heterogeneity as an explanation for previous inconsistent findings regarding the role of CRP in colorectal cancer etiology. The possible association in the subgroup with advanced tumors and shorter follow-up likely reflects undiagnosed cancer at baseline. Impact: Future efforts to establish the putative role of chronic, low-grade inflammation in colorectal cancer development will need to address the complex relationship between systemic inflammatory factors and tumor microenvironment, and might consider larger biomarker panels than CRP alone.

Place, publisher, year, edition, pages
American Association for Cancer Research , 2020. Vol. 29, no 7, p. 1482-1491
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-174012DOI: 10.1158/1055-9965.EPI-19-1339ISI: 000552627400026PubMedID: 32317300Scopus ID: 2-s2.0-85087470027OAI: oai:DiVA.org:umu-174012DiVA, id: diva2:1459061
Available from: 2020-08-19 Created: 2020-08-19 Last updated: 2023-03-23Bibliographically approved
In thesis
1. Inflammation and risk of chronic diseases with a focus on colorectal cancer and the impact of dietary patterns
Open this publication in new window or tab >>Inflammation and risk of chronic diseases with a focus on colorectal cancer and the impact of dietary patterns
2020 (English)Doctoral thesis, comprehensive summary (Other academic)
Alternative title[sv]
Inflammation och risk för kroniska sjukdomar med fokus på kolorektalcancer och inverkan av kostmönster
Place, publisher, year, edition, pages
Umeå, Sweden: Umeå university, 2020. p. 81
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 2099
Keywords
nutritional epidemiology, dietary patterns, epidemiology, cancer, colorectal cancer, chronic low-grade inflammation, biomarkers, metabolomics, nutritionsepidemiologi, kostmönster, epidemiologi, cancer, kolorektalcancer, kronisk låggradig inflammation, biomarkörer, metabolomik
National Category
Cancer and Oncology Public Health, Global Health, Social Medicine and Epidemiology Nutrition and Dietetics
Research subject
Epidemiology
Identifiers
urn:nbn:se:umu:diva-176737 (URN)978-91-7855-366-2 (ISBN)978-91-7855-365-5 (ISBN)
Public defence
2020-12-11, Hörsal B, Unod T9, Norrlands universitetssjukhus, Umeå, 09:00 (Swedish)
Opponent
Supervisors
Available from: 2020-11-20 Created: 2020-11-16 Last updated: 2022-05-12Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Bodén, StinaMyte, RobinSundkvist, AnneliZingmark, CarlLöfgren Burström, AnnaPalmqvist, RichardHarlid, Sophiavan Guelpen, Bethany

Search in DiVA

By author/editor
Bodén, StinaMyte, RobinHarbs, JustinSundkvist, AnneliZingmark, CarlLöfgren Burström, AnnaPalmqvist, RichardHarlid, Sophiavan Guelpen, Bethany
By organisation
OncologyPathologyWallenberg Centre for Molecular Medicine at Umeå University (WCMM)
In the same journal
Cancer Epidemiology, Biomarkers and Prevention
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 484 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf