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Unravelling the cellular emission fingerprint of the benchmark G-quadruplex-interactive compound Phen-DC3
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.ORCID iD: 0000-0002-7815-4494
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.ORCID iD: 0000-0001-6871-7663
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.ORCID iD: 0000-0003-0364-8964
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.ORCID iD: 0000-0002-4541-7702
2020 (English)In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 56, no 91, p. 14251-14254Article in journal (Refereed) Published
Abstract [en]

Phen-DC3 is among the most commonly used G-quadruplex (G4)-stabilizers in vitro and in cells. Here, we show that the G4-interactive binding interactions enable one to tune the optical properties of Phen-DC3 allowing the detection of G4 structures in cancer cells. This work opens up new directions for the use of Phen-DC3 as a selective G4 fluorescent reporter.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2020. Vol. 56, no 91, p. 14251-14254
National Category
Medical and Health Sciences Natural Sciences
Research subject
biological chemistry
Identifiers
URN: urn:nbn:se:umu:diva-176333DOI: 10.1039/d0cc05483fISI: 000590124000022PubMedID: 33118567Scopus ID: 2-s2.0-85096357070OAI: oai:DiVA.org:umu-176333DiVA, id: diva2:1484670
Funder
Knut and Alice Wallenberg Foundation, KAW2015-0189Swedish Research Council, VR-MH 2018-02651Swedish Cancer Society, CAN19 0126Available from: 2020-10-29 Created: 2020-10-29 Last updated: 2023-03-23Bibliographically approved

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Deiana, MarcoJamroskovic, JanObi, IkennaSabouri, Nasim

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