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Eradicating, retaining, balancing, swarming, shuttling and dumping: a myriad of tasks for neutrophils during fungal infection
Umeå University, Faculty of Medicine, Department of Clinical Microbiology. (Constantin Urban)ORCID iD: 0000-0003-1438-1134
Umeå University, Faculty of Medicine, Department of Clinical Microbiology. (Constantin Urban)
2020 (English)In: Current Opinion in Microbiology, ISSN 1369-5274, E-ISSN 1879-0364, Vol. 58, p. 106-115Article in journal (Refereed) Published
Abstract [en]

Opportunistic, invasive mycoses in immunocompromised patients remain challenging for health care with unacceptably high levels of morbidity and mortality. Neutrophils are essential in host protection against invasive mycoses. Upon development of acute infection, neutrophils are recruited from circulation to the infected tissue, where they exert a considerable variety of effector functions with the ultimate task to eradicate invading microbes. Effector functions include recognition, phagocytosis and intracellular killing of microorganisms via oxidative and non-oxidative mechanisms, excretion of antimicrobial factors from intracellular storages (degranulation), release of neutrophil extracellular traps (NETs) and of extracellular vesicles (EVs), as well as generation of cytokines and chemokines to modulate immune responses. Herein, we describe recent findings which further our understanding of the roles of neutrophils during opportunistic fungal infections which could serve as starting point for the development of immune-targeted interventions to improve clinical management of affected individuals.

Place, publisher, year, edition, pages
Elsevier, 2020. Vol. 58, p. 106-115
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-176945DOI: 10.1016/j.mib.2020.09.011ISI: 000601245600016PubMedID: 33091824Scopus ID: 2-s2.0-85092790416OAI: oai:DiVA.org:umu-176945DiVA, id: diva2:1502496
Funder
Swedish Research Council, 2017-01681Available from: 2020-11-20 Created: 2020-11-20 Last updated: 2023-03-23Bibliographically approved

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Urban, Constantin F.Backman, Emelie

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