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Co- and polymicrobial infections in the gut mucosa: the host-microbiota-pathogen perspective
Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).ORCID iD: 0000-0002-1209-0942
2021 (English)In: Cellular Microbiology, ISSN 1462-5814, E-ISSN 1462-5822, Vol. 23, no 2, article id e13279Article, review/survey (Refereed) Published
Abstract [en]

Infections in humans occur in the context of complex niches where the pathogen interacts with both the host microenvironment and immune response, and the symbiotic microbial community. The polymicrobial nature of many human infections adds a further layer of complexity. The effect of co- or polymicrobial infections can result in enhanced severity due to pathogens cooperative interaction or reduced morbidity because one of the pathogens affects the fitness of the other(s). In this review, the concept of co-infections and polymicrobial interactions in the context of the intestinal mucosa is discussed, focusing on the interplay between the host, the microbiota and the pathogenic organisms. Specifically, we will examine examples of pathogen-cooperative versus -antagonistic behaviour during co- and polymicrobial infections. We discuss: the infection-induced modulation of the host microenvironment and immune responses; the direct modulation of the microorganism's fitness; the potentiation of inflammatory/carcinogenic conditions by polymicrobial biofilms; and the promotion of co-infections by microbial-induced DNA damage. Open questions in this very exciting field are also highlighted.

Place, publisher, year, edition, pages
John Wiley & Sons, 2021. Vol. 23, no 2, article id e13279
Keywords [en]
bacteria, co-infections, disease progression, fungi, microbiota, mucosal microenvironment, parasites, polymicrobial infections, viruses
National Category
Microbiology
Identifiers
URN: urn:nbn:se:umu:diva-176444DOI: 10.1111/cmi.13279ISI: 000580988900001PubMedID: 33040471Scopus ID: 2-s2.0-85093496587OAI: oai:DiVA.org:umu-176444DiVA, id: diva2:1502533
Available from: 2020-11-20 Created: 2020-11-20 Last updated: 2023-03-24Bibliographically approved

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Frisan, Teresa

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