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EvaLuation Using Cardiac Insertable Devices And TelephonE in Hypertrophic Cardiomyopathy (ELUCIDATE HCM): A prospective observational study on incidence of arrhythmias
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Medicine.
2021 (English)In: Cardiovascular Electrophysiology, ISSN 1045-3873, E-ISSN 1540-8167, Vol. 32, no 1, p. 129-135Article in journal (Refereed) Published
Abstract [en]

Background Hypertrophic cardiomyopathy (HCM) is a heterogeneous disease associated with arrhythmias. Non-sustained ventricular tachycardia (NSVT) is a risk factor for sudden cardiac death and part of the current risk stratification. Furthermore, atrial fibrillation (AF), which increases the risk of stroke, is believed to be common in HCM patients. Routine ambulatory monitoring captures the rhythm only periodically over 24-48 h; thus, the true burden of arrhythmia is unknown. The insertable cardiac monitor (ICM) should help determine a more realistic arrhythmia assessment in HCM patients. Objective The purpose of this study was to ascertain the incidence of NSVT, AF, and bradycardia in unselected HCM patients by the use of an ICM. Methods Thirty adults, mean age 49.9 +/- 12.3 years, 25 (83.3%) males were implanted with a Confirm Rx ICM. The monitoring application was installed on the patient's smartphone, which allowed for patient activation in case of symptoms. The ICM was programmed as follows: ventricular tachycardia (VT) >= 160 beats per minute (bpm) for >= 8 intervals, AF >= 2 min of duration, and bradycardia <= 40 bpm or pause >= 3.0 s. Results The mean calculated 5-year risk was 2.3%, and 29/30 of the patients had a risk <4%. During follow-up, AF was found in nine patients (30.0%). At least one episode of NSVT was detected in seven patients (23.3%). In 13 patients (43.3%), sinoatrial block/sinus arrest/sinus bradycardia were seen. No arrhythmia was detected in nine patients (30.0%). Conclusion In this first prospective study using an ICM, the arrhythmia burden in HCM patients yielded 30.0% AF and 23.3% NSVT.

Place, publisher, year, edition, pages
John Wiley & Sons, 2021. Vol. 32, no 1, p. 129-135
Keywords [en]
arrhythmia, atrial fibrillation, hypertrophic cardiomyopathy, insertable cardiac monitor, non‐, sustained ventricular tachycardia
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-176894DOI: 10.1111/jce.14792ISI: 000584551300001PubMedID: 33108031Scopus ID: 2-s2.0-85096724618OAI: oai:DiVA.org:umu-176894DiVA, id: diva2:1503159
Funder
Pfizer ABAstraZenecaNovo NordiskAvailable from: 2020-11-23 Created: 2020-11-23 Last updated: 2023-03-24Bibliographically approved

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Mörner, Stellan

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