Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Prospective role of thyroid disorders in monitoring COVID-19 pandemic
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). CSIR-Institute of Minerals & Materials Technology, Odisha, India.
2020 (English)In: Heliyon, E-ISSN 2405-8440, Vol. 6, no 12, article id e05712Article, review/survey (Refereed) Published
Abstract [en]

COVID-19 pandemic has affected more than 200 countries and 1.3 million individuals have deceased within eleven months. Intense research on COVID-19 occurrence and prevalence enable us to understand that comorbidities play a crucial role in spread and severity of SARS-CoV-2 infection. Chronic kidney disease, diabetes,respiratory diseases and hypertension are among the various morbidities that are prevalent in symptomatic COVID-19 patients. However, the effect of altered thyroid-driven disorders cannot be ignored. Since thyroid hormone critically coordinate and regulate the major metabolism and biochemical pathways, this review is on the potential role of prevailing thyroid disorders in SARS-CoV-2 infection. Direct link of thyroid hormone with several disorders such as diabetes, vitamin D deficiency, obesity, kidney and liver disorders etc. suggests that the prevailing thyroid conditions may affect SARS-CoV-2 infection. Further, we discuss the oxidative stress-induced aging is associated with the degree of SARS-CoV-2 infection. Importantly, ACE2 protein which facilitates the host-cell entry of SARS-CoV-2 using the spike protein, are highly expressed in individuals with abnormal level of thyroid hormone. Altogether, we report that the malfunction of thyroid hormone synthesis may aggravate SARS-CoV-2 infection and thus monitoring the thyroid hormone may help in understanding the pathogenesis of COVID-19.

Place, publisher, year, edition, pages
Elsevier, 2020. Vol. 6, no 12, article id e05712
Keywords [en]
Thyroid, COVID-19, Hypothyroid, Hyperthyroid, Oxidative stress, Aging, Biochemistry, Endocrinology, Toxicology, Epidemiology, SARS-CoV-2
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:umu:diva-179590DOI: 10.1016/j.heliyon.2020.e05712ISI: 000605645000026PubMedID: 33344794Scopus ID: 2-s2.0-85097769814OAI: oai:DiVA.org:umu-179590DiVA, id: diva2:1525537
Available from: 2021-02-04 Created: 2021-02-04 Last updated: 2023-03-23Bibliographically approved

Open Access in DiVA

fulltext(1065 kB)175 downloads
File information
File name FULLTEXT01.pdfFile size 1065 kBChecksum SHA-512
f6dac85bca8a1bf983458c39421760af27fc4e4546a4e26005615c345c41a611aae426230369397fdbc3fc8d7009cbfae196ddd2017abbbe99de7a75fb2da379
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Kumari, Kanchan

Search in DiVA

By author/editor
Kumari, Kanchan
By organisation
Department of Molecular Biology (Faculty of Medicine)
In the same journal
Heliyon
Infectious Medicine

Search outside of DiVA

GoogleGoogle Scholar
Total: 175 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 107 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf