Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • apa-6th-edition.csl
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The structure of enteric human adenovirus 41: A leading cause of diarrhea in children
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.ORCID iD: 0000-0003-2418-0061
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Section of Virology. Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Section of Virology. Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.
Show others and affiliations
2021 (English)In: Science Advances, E-ISSN 2375-2548, Vol. 7, no 2, article id eabe0974Article in journal (Refereed) Published
Abstract [en]

Human adenovirus (HAdV) types F40 and F41 are a prominent cause of diarrhea and diarrhea-associated mortality in young children worldwide. These enteric HAdVs differ notably in tissue tropism and pathogenicity from respiratory and ocular adenoviruses, but the structural basis for this divergence has been unknown. Here, we present the first structure of an enteric HAdV-HAdV-F41-determined by cryo-electron microscopy to a resolution of 3.8 angstrom. The structure reveals extensive alterations to the virion exterior as compared to nonenteric HAdVs, including a unique arrangement of capsid protein IX. The structure also provides new insights into conserved aspects of HAdV architecture such as a proposed location of core protein V, which links the viral DNA to the capsid, and assembly-induced conformational changes in the penton base protein. Our findings provide the structural basis for adaptation of enteric HAdVs to a fundamentally different tissue tropism.

Place, publisher, year, edition, pages
American Association for the Advancement of Science , 2021. Vol. 7, no 2, article id eabe0974
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-180151DOI: 10.1126/sciadv.abe0974ISI: 000606331400035PubMedID: 33523995Scopus ID: 2-s2.0-85099241558OAI: oai:DiVA.org:umu-180151DiVA, id: diva2:1532204
Available from: 2021-03-01 Created: 2021-03-01 Last updated: 2023-03-24Bibliographically approved

Open Access in DiVA

fulltext(5383 kB)209 downloads
File information
File name FULLTEXT01.pdfFile size 5383 kBChecksum SHA-512
9f2fda1db2bd95c9ff99f1877c2479a019f39ac51545fbb1ecfe04e7b6571221f2e5c0b44ad14b9b7a3114a99253d2bef949400a288101a94d8222fdad1e9f47
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Rafie, KarimLenman, AnnasaraRajan, AnandiArnberg, NiklasCarlson, Lars-Anders

Search in DiVA

By author/editor
Rafie, KarimLenman, AnnasaraRajan, AnandiArnberg, NiklasCarlson, Lars-Anders
By organisation
Molecular Infection Medicine Sweden (MIMS)Wallenberg Centre for Molecular Medicine at Umeå University (WCMM)Department of Medical Biochemistry and BiophysicsSection of Virology
In the same journal
Science Advances
Microbiology in the medical area

Search outside of DiVA

GoogleGoogle Scholar
Total: 209 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 1003 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • apa-6th-edition.csl
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf