Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
A mark of disease: How mRNA modifications shape genetic and acquired pathologies
Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy; The Epitran Cost Action Consortium, COST Action CA16120.
The Epitran Cost Action Consortium, COST Action CA16120; Department of Bioengineering, Gebze Technical University, Kocaeli, Turkey.
Umeå universitet, Medicinska fakulteten, Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM). The Epitran Cost Action Consortium, COST Action CA16120.ORCID-id: 0000-0002-5389-244X
The Epitran Cost Action Consortium, COST Action CA16120; Core Research Laboratory, ISPRO-Institute for Cancer Research, Prevention and Clinical Network, Firenze, Italy; Department of Medical Biotechnologies, Università di Siena, Siena, Italy.
Visa övriga samt affilieringar
2021 (Engelska)Ingår i: RNA: A publication of the RNA Society, ISSN 1355-8382, E-ISSN 1469-9001, Vol. 27, nr 4, s. 367-389Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

RNA modifications have recently emerged as a widespread and complex facet of gene expression regulation. Counting more than 170 distinct chemical modifications with far-reaching implications for RNA fate, they are collectively referred to as the epitranscriptome. These modifications can occur in all RNA species, including messenger RNAs (mRNAs) and noncoding RNAs (ncRNAs). In mRNAs the deposition, removal, and recognition of chemical marks by writers, erasers and readers influence their structure, localization, stability, and translation. In turn, this modulates key molecular and cellular processes such as RNA metabolism, cell cycle, apoptosis, and others. Unsurprisingly, given their relevance for cellular and organismal functions, alterations of epitranscriptomic marks have been observed in a broad range of human diseases, including cancer, neurological and metabolic disorders. Here, we will review the major types of mRNA modifications and editing processes in conjunction with the enzymes involved in their metabolism and describe their impact on human diseases. We present the current knowledge in an updated catalog. We will also discuss the emerging evidence on the crosstalk of epitranscriptomic marks and what this interplay could imply for the dynamics of mRNA modifications. Understanding how this complex regulatory layer can affect the course of human pathologies will ultimately lead to its exploitation toward novel epitranscriptomic therapeutic strategies.

Ort, förlag, år, upplaga, sidor
Cold Spring Harbor Laboratory Press (CSHL), 2021. Vol. 27, nr 4, s. 367-389
Nyckelord [en]
Cancer, Epitranscriptomics, Human disease, mRNA, Posttranscriptional regulation of gene expression, RNA modifications
Nationell ämneskategori
Cell- och molekylärbiologi Biokemi och molekylärbiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-182007DOI: 10.1261/rna.077271.120ISI: 000629533500002Scopus ID: 2-s2.0-85103017419OAI: oai:DiVA.org:umu-182007DiVA, id: diva2:1542061
Tillgänglig från: 2021-04-06 Skapad: 2021-04-06 Senast uppdaterad: 2023-09-05Bibliografiskt granskad

Open Access i DiVA

fulltext(997 kB)225 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 997 kBChecksumma SHA-512
e2582e4307d1195b1da3f22d449df9b6e25639d151aab1f3a3300f440fb4c2ae0e1e85d176862f6e6db91cae1bb46caa63c8a3e302142fa21e72bd059936e76b
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextScopus

Person

Groza, PaulaAguilo, Francesca

Sök vidare i DiVA

Av författaren/redaktören
Groza, PaulaAguilo, Francesca
Av organisationen
Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
I samma tidskrift
RNA: A publication of the RNA Society
Cell- och molekylärbiologiBiokemi och molekylärbiologi

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 226 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 633 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf