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Plasma Amyloid-β in Relation to Antibodies Against Herpes Simplex Virus, Cytomegalovirus, and Chlamydophila pneumoniae
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine. Department of Public Health and Caring Sciences, Geriatric Medicine, Uppsala University, Uppsala, Sweden.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Section of Virology.ORCID iD: 0000-0001-9094-319x
Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Statistics. Umeå University, Faculty of Social Sciences, Centre for Demographic and Ageing Research (CEDAR).ORCID iD: 0000-0002-1812-3581
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2021 (English)In: Journal of Alzheimer's Disease Reports, E-ISSN 2542-4823, Vol. 5, no 1, p. 229-235Article in journal (Refereed) Published
Abstract [en]

Background: Amyloid-β (Aβ), the key constituent of Alzheimer’s disease (AD) plaques, has antimicrobial properties.

Objective: To investigate the association between plasma Aβ and antibodies against the AD-related pathogens herpes simplex virus (HSV), cytomegalovirus (CMV), and C. pneumoniae.

Methods: Plasma from 339 AD cases, obtained on average 9.4 years (±4.00) before diagnosis, and their matched controls were analyzed for Aβ40 and Aβ42 concentrations with Luminex xMAP technology and INNOBIA plasma Aβ-form assays. Enzyme-linked immunosorbent assays were utilized for analyses of anti-HSV immunoglobulin (Ig) G, anti-HSV1 IgG, anti-HSV2 IgG, anti-CMV IgG, and anti-C. pneumoniae IgG. Follow-up samples were available for 150 of the cases.

Results: Presence and levels of anti-HSV1 IgG, anti-HSV2 IgG, anti-CMV IgG, and anti-C. pneumoniae IgG did not correlate with concentrations of Aβ42 or Aβ40 in cases or controls.

Conclusion: Levels of plasma Aβ were not associated with antibodies against different AD-related pathogens.

Place, publisher, year, edition, pages
IOS Press, 2021. Vol. 5, no 1, p. 229-235
Keywords [en]
Alzheimer’s disease, amyloid-β peptides, Chlamydophila pneumoniae, cytomegalovirus, dementia, Herpes simplex, nested case-control study
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
URN: urn:nbn:se:umu:diva-182612DOI: 10.3233/ADR-210008ISI: 000651079100025Scopus ID: 2-s2.0-85103991159OAI: oai:DiVA.org:umu-182612DiVA, id: diva2:1547584
Available from: 2021-04-27 Created: 2021-04-27 Last updated: 2023-09-05Bibliographically approved

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Lopatko Lindman, KarinWeidung, BodilOlsson, JanJosefsson, MariaJohansson, AndersEriksson, StureHallmans, GöranElgh, FredrikLövheim, Hugo

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Lopatko Lindman, KarinWeidung, BodilOlsson, JanJosefsson, MariaJohansson, AndersEriksson, StureHallmans, GöranElgh, FredrikLövheim, Hugo
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Geriatric MedicineSection of VirologyStatisticsCentre for Demographic and Ageing Research (CEDAR)Department of OdontologySection of Sustainable HealthNutritional ResearchWallenberg Centre for Molecular Medicine at Umeå University (WCMM)
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Journal of Alzheimer's Disease Reports
Gerontology, specialising in Medical and Health Sciences

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